ArticleEBioMedicine2026
Adverse and adaptive placental DNA methylation changes linking prenatal air pollution exposure to child lung function: findings from the SEPAGES cohort.
Article in EBioMedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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20 authors.
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Abstract
backgroundPrenatal air pollution exposure (PAPE) may have programming effects on offspring health. Placental epigenetic modifications are hypothesised to mediate this relationship, but evidence remains limited. We investigated the mediating role of placental DNA methylation (DNAm) in the association between prenatal exposure to NO
methodsPlacental DNAm was measured using the Infinium HumanMethylationEPIC BeadChip in 395 participants from the French cohort SEPAGES. PAPE was estimated via personal sensors. Lung function (6 parameters) was measured at two months through tidal breathing analysis and nitrogen multiple breath washout test. We conducted adjusted epigenome-wide mediation analyses to identify genomic loci (CpGs and aggregated methylated regions; AMRs) that explain the association between PAPE and offspring lung function.
findingsThirty CpGs and 166 AMRs significantly mediated the PAPE-lung function relationship. Most mediators were involved in the effect of PM
interpretationOur findings provide insights into the epigenetic pathways linking PAPE to early-life lung function. They highlight the placenta as a critical interface, where both detrimental and compensatory epigenetic modifications may shape newborn lung function.
fundingFrench Agency for National Research.
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