ArticleAnimal bioscience2026
Dietary supplementation of cysteamine promotes Hu lamb growth performance via somatotropic axis potentiation.
Article in Animal bioscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveCysteamine (CS) is known for its ability to regulate hormone secretion. Although widely used as a growth promoter for ruminants, long-term administration at high doses results in intestinal ulceration and growth retardation. We have previously demonstrated that long-term supplementing 20 mg CS/kg body weight (BW) does not affect growth performance.
methodsThis study aimed to elucidate the impacts of 30 mg CS kg-1 BW administered for 30 days on growth performance, hormonal profiles, rumen fermentation parameters, rumen bacterial communities, and muscle characteristics in Hu lambs. This dosage and duration regimen was effective in promoting growth performance while avoiding the ruminal negative effects observed at higher doses. Thirty-six male Hu lambs were randomly assigned to two groups.
resultsThe CS supplementation exhibited increased final BW, average daily gain, and dry matter intake during the first 21 days of the experimental period (p<0.05). Hormonal analysis revealed that CS supplementation increased the levels of growth hormone, luteinizing hormone in the pituitary, testosterone (T) in the testis, and insulin-like growth factor I in the serumwhile decreasing the levels of somatostatin in the hypothalamus and serum (p<0.05). Rumen fermentation analysis indicated an increase in total volatile fatty acids and the proportion of valerate (p<0.05), while the proportion of acetate and the acetate/propionate ratio decreased (p<0.05). Muscle analysis revealed decreased mRNA expression levels of MyHCIIb (p<0.05) in the longissimus dorsi muscle. Western blot analysis showed increased expression of mTOR proteins, along with an elevated phosphorylation level of mTOR (p<0.05) in the longissimus dorsi muscle.
conclusionCollectively, this study demonstrates that dietary CS supplementation enhances growth performance in Hu lambs by improving rumen function and modulating somatotropic axis hormones.
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