Evidence map›Paper›PMID 42343084›Full record

ArticleScientific reports2026

Assessing autonomic nervous system imbalance in long COVID-19 patients through heart rate variability during tilt testing.

Samuel Minucci Camargo, Ana Leticia Gomes Dos Santos, Stella Tassinari Maximo, Kelly Correa Baioco da Silva, Beatriz de Oliveira Machado, Christian Gonçalves Sassaki, Silvia Helena Bastos de Paula, José Luis Puglisi, Daniel Gustavo Goroso

Abstract read
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Samuel Minucci CamargoBiological Systems Modeling and Signal Processing Laboratory, Center for Technological Research, Universidade de Mogi das Cruzes, Av. Dr. Cândido X. de Almeida e Souza, 200 - Centro Civico, Mogi das Cruzes, SP, 08780-911, Brazil.ORCID 0000-0001-7640-2194
Ana Leticia Gomes Dos SantosBiological Systems Modeling and Signal Processing Laboratory, Center for Technological Research, Universidade de Mogi das Cruzes, Av. Dr. Cândido X. de Almeida e Souza, 200 - Centro Civico, Mogi das Cruzes, SP, 08780-911, Brazil.ORCID 0009-0000-5551-0145
Stella Tassinari MaximoFaculdade de Medicina São Leopoldo Mandic, Araras, SP, Brasil.ORCID 0009-0009-3749-2188
Kelly Correa Baioco da SilvaBiological Systems Modeling and Signal Processing Laboratory, Center for Technological Research, Universidade de Mogi das Cruzes, Av. Dr. Cândido X. de Almeida e Souza, 200 - Centro Civico, Mogi das Cruzes, SP, 08780-911, Brazil.ORCID 0009-0002-6227-6814
Beatriz de Oliveira MachadoFaculdade de Medicina, Universidade de Mogi das Cruzes, Mogi das Cruzes, SP, Brasil.ORCID 0009-0004-8296-6411
Christian Gonçalves SassakiBiological Systems Modeling and Signal Processing Laboratory, Center for Technological Research, Universidade de Mogi das Cruzes, Av. Dr. Cândido X. de Almeida e Souza, 200 - Centro Civico, Mogi das Cruzes, SP, 08780-911, Brazil.ORCID 0009-0004-7484-0640
Silvia Helena Bastos de PaulaInstituto de Saúde, Secretaria de Estado da Saúde de São Paulo (IS-SESSP), São Paulo, SP, Brasil.ORCID 0000-0002-4405-9405
José Luis PuglisiCollege of Medicine, California Northstate University, Elk Grove, CA, USA.ORCID 0000-0003-0241-8446
Daniel Gustavo GorosoBiological Systems Modeling and Signal Processing Laboratory, Center for Technological Research, Universidade de Mogi das Cruzes, Av. Dr. Cândido X. de Almeida e Souza, 200 - Centro Civico, Mogi das Cruzes, SP, 08780-911, Brazil. danielg@umc.br.ORCID 0000-0001-5454-9873

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 164066/2024-1Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 88887.941749/2024-00Fundação de Amparo à Pesquisa do Estado de São Paulo 2021/14231-0
6 · The paper itself

Abstract

Long COVID-19 is recognized as a condition associated with autonomic nervous system (ANS) dysfunction. However, quantitative evidence of its impact on heart rate variability (HRV) and blood pressure (BP) regulation during postural changes remains limited. This study assessed autonomic imbalance in post-COVID-19 patients by evaluating HRV and BP responses during tilt table testing, comparing long COVID-19 patients with healthy controls. A total of 61 participants were enrolled, 39 long COVID-19 patients (Study Group, SG) and 22 healthy controls (Control Group, CG). HRV was analyzed using time- and frequency-domain parameters. BP monitoring evaluated systolic, and diastolic blood pressure (SBP, and DBP respectively), and Pulse pressure (PP = SBP-DBP) was calculated for each phase. SG participants exhibited marked autonomic dysfunction during tilt. In the upright phase, they showed a significant increase in mean RR intervals (p = 0.0136), reduced normalized low-frequency (LF

Indexed as

Autonomic Nervous SystemCOVID-19Heart RateTilt-Table TestAdultBlood PressureCase-Control StudiesFemaleHumansMaleMiddle AgedPost-Acute COVID-19 SyndromePostureSARS-CoV-2Autonomic nervous system (ANS)Cardiovascular dysregulationHeart rate variability (HRV)Long COVID-19Postural orthostatic tachycardia syndrome (POTS)Tilt table test

Identifiers

PMID42343084
PMCPMC13569858

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.