Evidence map›Paper›PMID 42343635›Full record

ArticleJournal of Zhejiang University. Science. B2026

Esculetin attenuates migraine-like pain via CGRP suppression and meningeal mast cell modulation in rat models.

Ayca Nur Gonul, Ibrahim Ethem Torun, Yasemin Baranoglu Kilinc, Erkan Kilinc

Abstract read
In one paragraph

Article in Journal of Zhejiang University. Science. B, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ayca Nur GonulDepartment of Physiology, Faculty of Medicine, Bolu Abant Izzet Baysal University, Bolu 14030, Türkiye.
Ibrahim Ethem TorunDepartment of Physiology, Faculty of Medicine, Bolu Abant Izzet Baysal University, Bolu 14030, Türkiye.
Yasemin Baranoglu KilincDepartment of Pediatrics, Faculty of Medicine, Bolu Abant Izzet Baysal University, Bolu 14030, Türkiye.
Erkan KilincDepartment of Physiology, Cerrahpasa Faculty of Medicine, İstanbul University-Cerrahpaşa, İstanbul 34098, Türkiye. erkan.kilinc@iuc.edu.tr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Growing evidence suggests that esculetin, a 5-lipoxygenase inhibitor, has pharmacotherapeutic potential due to its various pharmacological properties, such as potent anti-inflammatory, anti-nociceptive, and γ-aminobutyric acid type A (GABA

Indexed as

Calcitonin Gene-Related PeptideMast CellsMeningesMigraine DisordersUmbelliferonesAnimalsDisease Models, AnimalHyperalgesiaMaleRatsRats, Sprague-DawleyCalcitonin Gene-Related PeptideesculetinUmbelliferonesCalcitonin gene-related peptide (CGRP)EsculetinMast cellsNatural compoundNeuroinflammationNitroglycerin model

Identifiers

PMID42343635
PMCPMC13294283

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.