ArticleOncology reviews2026
Association of MMP-2 and hematological parameters with breast cancer metastasis: a cross-sectional study in Central Java, Indonesia.
Article in Oncology reviews, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Breast cancer metastasis remains a major contributor to morbidity and mortality, partly due to the disease's marked biological heterogeneity. Identification of reliable biomarkers associated with metastatic progression is essential for improving risk stratification and clinical management. Matrix metalloproteinase-2 (MMP-2) and routine hematological and metabolic parameters have been implicated in cancer progression, but their roles in breast cancer metastasis remain inconsistent across populations. Methods: This cross-sectional study evaluated general, hematological and metabolic parameters in breast cancer patients from Dr. Kariadi General Hospital, the main referral hospital for Central Java, Indonesia. Associations with metastasis were assessed using univariate analyses, followed by least absolute shrinkage and selection operator (LASSO) logistic regression for variable selection. Multicollinearity was assessed using variance inflation factor (VIF), and selected variables were entered simultaneously into a multivariable binary logistic regression model. Associations between selected hematological parameters and estrogen receptor (ER) and progesterone receptor (PR) status were also examined. Associations between clinicopathological variables and histologic grade were analyzed using the Kruskal-Wallis test. Results: Histologic grade was the only general characteristic significantly associated with metastasis ( Conclusion: Elevated MMP-2 levels and reduced platelets were independently associated with breast cancer metastasis, while platelets were additionally associated with ER status. These findings suggest that MMP-2 and platelet count may serve as potential biomarkers associated with metastatic behavior and hormone receptor status in breast cancer.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.