Evidence map›Paper›PMID 42343978›Full record

ArticleTH open : companion journal to thrombosis and haemostasis2026

DNA Methylation Variation in Blood Cells may Impact Platelet Function.

Jillian Teichman, Ming-Huei Chen, Florian Thibord, Melissa V Chan, Bongani B Nkambule, Amber R Lachapelle, Jiantao Ma, Roby Joehanes, Chunyu Liu, Angel M Aponte and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in TH open : companion journal to thrombosis and haemostasis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jillian TeichmanThe Framingham Heart StudyNational Heart, Lung, and Blood Institute, National Institutes of HealthFraminghamMassachusettsUnited States.ORCID 0009-0004-6742-9087
Ming-Huei ChenThe Framingham Heart StudyNational Heart, Lung, and Blood Institute, National Institutes of HealthFraminghamMassachusettsUnited States.
Florian ThibordThe Framingham Heart StudyNational Heart, Lung, and Blood Institute, National Institutes of HealthFraminghamMassachusettsUnited States.
Melissa V ChanThe Framingham Heart StudyNational Heart, Lung, and Blood Institute, National Institutes of HealthFraminghamMassachusettsUnited States.
Bongani B NkambuleThe Framingham Heart StudyNational Heart, Lung, and Blood Institute, National Institutes of HealthFraminghamMassachusettsUnited States.ORCID 0000-0001-8846-1992
Amber R LachapelleThe Framingham Heart StudyNational Heart, Lung, and Blood Institute, National Institutes of HealthFraminghamMassachusettsUnited States.
Jiantao MaPopulation Sciences BranchDivision of Intramural ResearchNational Heart, Lung, and Blood Institute, National Institutes of HealthFraminghamMassachusettsUnited States.
Roby JoehanesThe Framingham Heart StudyNational Heart, Lung, and Blood Institute, National Institutes of HealthFraminghamMassachusettsUnited States.
Chunyu LiuThe Framingham Heart StudyNational Heart, Lung, and Blood Institute, National Institutes of HealthFraminghamMassachusettsUnited States.
Angel M ApontePopulation Sciences BranchDivision of Intramural ResearchNational Heart, Lung, and Blood Institute, National Institutes of HealthBethesdaMarylandUnited States.
Sumith R PanickerSection of Vascular Thrombosis and InflammationDivision of Intramural ResearchNational Heart, Lung, and Blood Institute, National Institutes of HealthBethesdaMarylandUnited States.
Yogendra KanthiSection of Vascular Thrombosis and InflammationDivision of Intramural ResearchNational Heart, Lung, and Blood Institute, National Institutes of HealthBethesdaMarylandUnited States.
Daniel LevyThe Framingham Heart StudyNational Heart, Lung, and Blood Institute, National Institutes of HealthFraminghamMassachusettsUnited States.
Andrew D JohnsonThe Framingham Heart StudyNational Heart, Lung, and Blood Institute, National Institutes of HealthFraminghamMassachusettsUnited States.ORCID 0000-0001-6369-5178

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

DNA methylation modifies nucleotides, regulating gene expression without sequence change. The effects of DNA methylation within blood cell lineages on the development and function of endomitotic high DNA copy megakaryocytes (MKs) to anucleate platelets remain poorly understood. We sought to characterize this potential relationship by investigating associations between platelet function and methylation in circulating nucleated blood cells. Data were measured in the Framingham Heart Study Third Generation cohort (

Indexed as

DNA methylationepigenomeEWASmegakaryocytesplatelet reactivity

Identifiers

PMID42343978
PMCPMC13289646

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.