ArticleChemical science2026
Orthogonal nanopores cross-validation for multiplex single-molecule profiling.
Article in Chemical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Identification and Discrimination of Sulfated and Unsulfated Gut-Hormone Biomarkers in Human Serum by Nanopore.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multiplex biomolecule profiling provides comprehensive molecular insights essential for precision health diagnosis. Yet, achieving simultaneous analysis of diverse biomolecule types, such as DNAs, RNAs, peptides, oligosaccharides, and metabolites, remains challenging due to their fundamentally diversity including size, charge, structure, and chemical composition. We present a nanopore multiplex sensor (NMS) based on a bioelectronic microchip that enables concurrent profiling of multiple biomolecules in a single experiment, which was previously unattainable. Cross-validation using multiple types of orthogonal nanopores with complementary recognition abilities offered the simultaneous detection and relative quantification of five major types of biomolecules relevant to non-small-cell lung cancer. Our work establishes a robust and generalizable nanopore platform for rapid and parallel biomarker sensing, providing an important step toward addressing the vital challenge of single-molecule multiomics.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.