ArticleVeterinary world2026
Concurrent infection with piscine intestinal coccidia and infectious spleen and kidney necrosis virus associated with mass mortality and severe gastrointestinal pathology in juvenile
Article in Veterinary world, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background and Aim: Concurrent infections in aquaculture species often exacerbate disease severity and complicate diagnosis and control strategies. This study investigated the pathological and molecular characteristics of co-infection with piscine intestinal coccidia and infectious spleen and kidney necrosis virus (ISKNV) associated with mass mortality in juvenile Materials and Methods: A total of 20 moribund juvenile Results: All examined fish (100%) were concurrently infected with piscine intestinal coccidia and ISKNV, indicating a strong association with the observed outbreak. Clinically, fish exhibited emaciation, discoloration, and visceral congestion. Histopathology revealed systemic ISKNV infection characterized by basophilic hypertrophic (megalocytic) cells in multiple organs, while coccidia were localized within the intestinal epithelium at epicellular, intracellular, and subepithelial positions. Severe gastrointestinal lesions, including inflammation, epithelial desquamation, and necrosis, were markedly intensified in co-infected tissues. SEM demonstrated rough-surfaced, oval oocysts consistent with piscine intestinal coccidia. Molecular analysis confirmed the presence of ISKNV, with Conclusion: This study provides the first comprehensive evidence of concurrent infection with piscine intestinal coccidia and ISKNV as a significant cause of mass mortality in juvenile
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