ArticleVeterinary world2026
Dose-dependent effects of locally produced microbial phytase on caecal microbiota, hepatic insulin-like
Article in Veterinary world, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background and Aim: Microbial phytase is extensively used in poultry nutrition to improve phosphorus utilization and reduce the anti-nutritional effects of phytic acid. Beyond nutrient digestibility, phytase may influence intestinal microbiota, immune responses, and growth-related molecular pathways in broiler chickens. However, limited information is available regarding the integrated effects of locally produced microbial phytase on caecal microbial populations, hepatic growth-related gene expression, carcass characteristics, and humoral immunity under the same experimental conditions. Therefore, this study evaluated the dose-dependent effects of dietary microbial phytase supplementation on caecal microbiota, hepatic expression of Materials and Methods: A total of 576 day-old Cobb 500 broiler chicks were randomly assigned to six dietary treatments under a completely randomized design. T1 received a basal diet without phytase supplementation, whereas T2-T6 received basal diets supplemented with microbial phytase at 200, 300, 400, 500, and 600 FTU/kg, respectively. Each treatment consisted of eight replicates with 12 birds per replicate. The experiment lasted for 35 days, covering starter, grower, and finisher phases. Caecal microbial populations were determined using selective culture techniques. Plasma immunoglobulin A and immunoglobulin G concentrations were quantified using enzyme-linked immunosorbent assay kits. Hepatic Results: Dietary microbial phytase supplementation significantly increased beneficial caecal bacteria, including Discussion: Locally produced microbial phytase demonstrated multifunctional physiological benefits beyond phosphorus release by improving gut microbial balance, humoral immunity, hepatic growth-related gene expression, and carcass performance in broiler chickens. Supplementation at 600 FTU/kg yielded the greatest overall biological responses and may represent an effective nutritional strategy to improve poultry productivity and intestinal health under tropical production conditions.
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