ArticleRegenerative biomaterials2026
An immunomodulatory decellularized pulp matrix hydrogel promotes vascularized dental pulp regeneration through angiogenic-odontogenic coupling.
Article in Regenerative biomaterials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
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Abstract
Maintaining the vitality of inflamed or exposed pulp is critical for long-term tooth preservation in clinical dentistry. Vital pulp therapy (VPT), achieved by placing bioactive materials over the exposed pulp tissue, aims to preserve pulp function and stimulate dentin-pulp healing. However, effective regeneration requires biomaterials capable of orchestrating early inflammatory resolution, immune modulation and coordinated angiogenic-odontogenic responses. Here, we engineered an injectable porcine-derived decellularized dental pulp matrix (pDPM) hydrogel with intrinsic immunomodulatory properties to promote vascularized dental pulp regeneration. The pDPM retained abundant pulp-specific extracellular matrix components and bioactive factors while displaying excellent biocompatibility.
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