SynthesisFrontiers in medicine2026
The evolving role of regulatory T cells in pulmonary diseases: immunomodulatory mechanisms and translational directions revealed by bibliometric analysis.
Synthesis in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
Funding
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Abstract
Background: Regulatory T cells (Tregs) play important roles in immune homeostasis and pulmonary disease progression. However, the global research landscape, thematic evolution, and emerging frontiers of Treg research in pulmonary diseases remain unclear. This study aimed to systematically characterize research trends and knowledge structures in this field using bibliometric methods. Methods: A total of 9,079 deduplicated publications related to Tregs in pulmonary diseases were retrieved from the Web of Science Core Collection and Scopus databases from 2000 to 2025. Bibliometric and visualization analyses were performed to evaluate publication trends, country contributions, collaboration networks, keyword co-occurrence, co-citation patterns, and emerging hotspots. Results: The field exhibited a tri-phasic growth pattern: a slow initial phase (2000-2008), a rapid growth phase (2009-2019), and the current high-output phase (2020-present). The United States played a dominant role in the early period, while China has emerged as the top-producing country annually since 2021. Keyword co-occurrence and co-citation analyses revealed a thematic shift from foundational immune regulation and cytokine networks toward emerging translational topics, including immunotherapy, the tumor microenvironment, microbiota-associated immune regulation, and chronic inflammatory lung diseases.The analyses also identified the most prominent keywords, clusters, and highly cited references that together define the evolving knowledge structure of Treg research in pulmonary diseases. Conclusion: This bibliometric analysis provides a comprehensive overview of global trends and emerging frontiers in Treg research in pulmonary diseases. Emerging therapeutic strategies suggested in the literature, including targeting Tregs, the tumor microenvironment, or the gut microbiota, may guide future translational research and precision immunotherapy development in pulmonary diseases.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.