Evidence map›Paper›PMID 42344584›Full record

ArticleEnvironment & health (Washington, D.C.)2026

Prenatal Exposure to PFOA Induces Ovarian Function Impairment via the Disruption of the PPARγ/ANGPTL4 Pathway.

Tongyun Qi, Huiyu Fan, Wenxian Xu, Yizhou Huang, Lilai Shen, Saisai Li, Shulin Zhuang, Jianhong Zhou, Chunming Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environment & health (Washington, D.C.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tongyun QiDepartment of Gynecology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
Huiyu FanDepartment of Gynecology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China.
Wenxian XuDepartment of Gynecology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China.
Yizhou HuangDepartment of Gynecology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China.
Lilai ShenState Key Laboratory of Soil Pollution Control and Safety, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China.
Saisai LiDepartment of Gynecology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China.
Shulin ZhuangDepartment of Gynecology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China.ORCID https://orcid.org/0000-0002-7774-7239
Jianhong ZhouDepartment of Gynecology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China.
Chunming LiDepartment of Gynecology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China.ORCID https://orcid.org/0009-0009-5189-8723

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Perfluorooctanoic acid (PFOA) has been implicated in female reproductive toxicity, while its long-term effects of prenatal exposure remain unclear. Herein, we conducted a comprehensive NHANES analysis to estimate the Hazard Ratio (HR) of earlier menopause associated with PFOA exposure and further investigated the underlying mechanisms through a prenatal mouse model and complementary cell-based assays. Higher serum PFOA levels were significantly associated with earlier age at natural menopause (2nd tertile: HR = 1.220,

Indexed as

granulosa cell proliferationovarian function impairmentperfluorooctanoic acidPPARγ signalingprenatal exposure

Identifiers

PMID42344584
PMCPMC13288232

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.