ArticleFrontiers in oncology2026
Chronic military stress and glandular epithelial tumor biology: an integrative neuroendocrine-inflammatory framework with insights from microgravity gene discovery.
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- The biological state hypothesis: biological state as a systems-level constraint on human adaptive capacity.Frontiers in physiology · 2026Article
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14 authors.
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Abstract
Exposure to extreme stress within military contexts such as combat, captivity, survival training, or blast exposure triggers complex neurobiological responses that, in susceptible individuals, culminate in conditions such as Post-Traumatic Stress Disorder (PTSD). This inter-individual variability is rooted in profound genetic and epigenetic foundations. This manuscript reviews the critical relationship between chronic military stress and five key molecules: the glucocorticoid receptor (NR3C1), the FK506-binding protein 5 (FKBP5), brain-derived neurotrophic factor (BDNF), neuropeptide Y (NPY), and interleukin-6 (IL6). We examine how the dysregulation of this allostatic network predisposes individuals to PTSD and generates an altered systemic inflammatory and neuroendocrine microenvironment. Seeking an integrative biological perspective, this pathogenic model is linked to discoveries derived from extreme physical environments. Previous investigations by our group involving
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.