Evidence map›Paper›PMID 42344803›Full record

ArticleFrontiers in pharmacology2026

Effect of combined aspirin and statin therapy on mortality reduction in sepsis-induced myocardial injury.

Yunzhang Zhao, Xuan Zhang, Shuai Mao, Huiyi Liu, Chao Lv, Yanzhu Yao, Yuyan Wang, Yifan Wang, Shengshu Wang, Yong Xu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yunzhang Zhao *Institute of Geriatrics, National Clinical Research Center for Geriatric Diseases, Second Medical Center of Chinese PLA General Hospital, Beijing, China.
Xuan Zhang *Department of Medical Innovation Research, Chinese PLA General Hospital, Beijing, China.
Shuai Mao *Institute of Geriatrics, National Clinical Research Center for Geriatric Diseases, Second Medical Center of Chinese PLA General Hospital, Beijing, China.
Huiyi LiuInstitute of Geriatrics, National Clinical Research Center for Geriatric Diseases, Second Medical Center of Chinese PLA General Hospital, Beijing, China.
Chao LvInstitute of Geriatrics, National Clinical Research Center for Geriatric Diseases, Second Medical Center of Chinese PLA General Hospital, Beijing, China.
Yanzhu YaoInstitute of Geriatrics, National Clinical Research Center for Geriatric Diseases, Second Medical Center of Chinese PLA General Hospital, Beijing, China.
Yuyan WangInstitute of Geriatrics, National Clinical Research Center for Geriatric Diseases, Second Medical Center of Chinese PLA General Hospital, Beijing, China.
Yifan WangInstitute of Geriatrics, National Clinical Research Center for Geriatric Diseases, Second Medical Center of Chinese PLA General Hospital, Beijing, China.
Shengshu WangInstitute of Geriatrics, National Clinical Research Center for Geriatric Diseases, Second Medical Center of Chinese PLA General Hospital, Beijing, China.
Yong XuMedical School of Chinese PLA, Chinese PLA General Hospital, Beijing, China.
Tong YinInstitute of Geriatrics, National Clinical Research Center for Geriatric Diseases, Second Medical Center of Chinese PLA General Hospital, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Sepsis-induced myocardial injury (SIMI) is a severe complication with high mortality and limited effective treatments. Although combined aspirin and statin therapy is cardioprotective in coronary artery disease, its impact on SIMI outcomes remains unclear. Methods: Using the MIMIC-IV database, we evaluated the association of combined aspirin and statin therapy with 28-day, 90-day, and 1-year mortality in SIMI patients using multivariable Cox regression and Kaplan-Meier analysis. Robustness was assessed via floating absolute risk analysis. External validation was performed in an independent ICU cohort. Results: Among 1,884 SIMI patients, 119 received combination therapy. Compared to those without aspirin or statin, combination therapy was associated with significantly lower mortality at 28 days (11.8% vs. 41.9%; HR = 0.22), 90 days (15.1% vs. 44.8%; HR = 0.23), and 1 year (29.4% vs. 50.9%; HR = 0.38) (all Conclusion: Combined aspirin and statin therapy is associated with reduced mortality and improved outcomes in SIMI patients.

Indexed as

aspirincombined therapymortalitysepsis-induced myocardial injurystatin

Identifiers

PMID42344803
PMCPMC13286924

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.