ReviewCureus2026
Effects of a Gluten-Free Diet on Gastrointestinal Symptoms and Quality of Life in Non-celiac Gluten-Related Disorders: A Systematic Review and Meta-Analysis.
Review in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
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Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Non-celiac gluten sensitivity (NCGS) is a gastrointestinal and extraintestinal condition characterized by symptoms triggered by the ingestion of gluten, but it does not involve celiac disease (CD) or an allergic reaction to wheat. This meta-analysis and systematic evaluation were intended to determine the impact of a gluten-free diet (GFD) on gastrointestinal symptom reduction and quality of life (QoL) in NCGS patients. We filtered studies published from 2010 to 2025, focusing on randomized controlled trials and observational studies. The findings showed that GFD significantly promoted gastrointestinal signs and symptoms and QoL, and the pooled effect was 0.88 (95% CI = 0.20-1.55), which showed a marginal effect. Nonetheless, significant heterogeneity was observed (I² = 97.77%), suggesting that variability in effects may be attributed to differences in study design, participant characteristics, and adherence to the diet. Subgroup analysis suggested a larger pooled effect among participants with NCGS (pooled effect size = 0.93) than among participants with CD or less clearly defined gluten-related sensitivity (pooled effect size = 0.74). However, high heterogeneity within the NCGS subgroup indicates the need for further well-designed studies. The evaluation indicates that adherence and baseline symptom severity are key factors influencing the efficacy of diet. Publication bias was not identified as a major concern, as suggested by the relatively symmetrical funnel plot and the non-significant results of the statistical tests. Overall, this meta-analysis suggests that a GFD may be a useful intervention for patients with NCGS; however, individualized dietary management is needed because responses may vary across patients.
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