Evidence map›Paper›PMID 42344829›Full record

ReviewCureus2026

Sodium-Glucose Cotransporter 2 Inhibitors Versus Dipeptidyl Peptidase-4 Inhibitors in Patients With Type 2 Diabetes Mellitus and Liver Cirrhosis: A Systematic Review and Meta-Analysis.

Uday Shree Akkala Shetty, Ansharah-E-Zinnia Batool, Anastasia Postoev, Rahman Hameed Mohammed Abdul, Sonalben Chaudhary, Sidra Jabeen, Calvin R Wei, Adil Amin

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Uday Shree Akkala ShettyInternal Medicine, Southern Regional Medical Center, Riverdale, GEO.
Ansharah-E-Zinnia BatoolMedicine, Rashid Latif Medical College, Lahore, PAK.
Anastasia PostoevInternal Medicine, Caribbean Medical University, Willemstad, CUW.
Rahman Hameed Mohammed AbdulGastroenterology and Hepatology, King's Mill Hospital, Sutton-In-Ashfield, GBR.
Sonalben ChaudharyInternal Medicine, Zydus Sitapur Hospital, Sitapur, IND.
Sidra JabeenMedicine, Latin American School of Medicine (ELAM), Sancti Spiritus, CUB.
Calvin R WeiResearch and Development, Shing Huei Group, Taipei, TWN.
Adil AminCardiology, Pakistan Navy Ship Shifa, Karachi, PAK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Liver cirrhosis complicated by type 2 diabetes mellitus (T2DM) is associated with significantly increased risks of hepatic decompensation, infection, and mortality. The optimal antidiabetic strategy in this population remains poorly defined, with limited evidence directly comparing available agents. This meta-analysis compared the clinical effectiveness of sodium-glucose cotransporter-2 inhibitors (SGLT2i) versus dipeptidyl peptidase-4 inhibitors (DPP4i) in patients with established liver cirrhosis. A systematic search of MEDLINE, EMBASE, Cochrane CENTRAL, and Web of Science was conducted up to 15 April 2026. Four retrospective observational cohort studies enrolling 25,000 patients with established cirrhosis and T2DM were included. All-cause mortality showed a pooled risk ratio of 0.64 (95% CI: 0.34-1.23; I

Indexed as

dpp-4 inhibitorshepatic decompensationliver cirrhosismeta-analysissglt2 inhibitors

Identifiers

PMID42344829
PMCPMC13288039

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.