ArticleFrontiers in nutrition2026
Association between serum 25-hydroxyvitamin D concentrations and overactive bladder in female: a mediation analysis of inflammatory biomarkers.
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Overactive bladder (OAB) is a prevalent condition that substantially impairs quality of life. Although 25-hydroxyvitamin D [25(OH)D] plays an important role in immune modulation, its association with OAB and the potential contribution of inflammation remain incompletely understood. Methods: We analyzed 25,096 participants from National Health and Nutrition Examination Survey (NHANES) 2007-2018 and 2,442 participants from a hospital-based replication cohort (FAH-DMU-DB) using multivariable logistic regression and restricted cubic spline models. Inflammatory biomarkers were incorporated to evaluate their influence on the association between 25(OH)D and OAB. A two-sample Mendelian randomization (MR) analysis was additionally performed to assess potential relationship. Results: In the NHANES cohort, higher serum 25(OH)D levels were inversely associated with the risk of OAB among females but not males. Female in the highest quartile of 25(OH)D exhibited a significantly lower risk of OAB compared with those in the lowest quartile (OR = 0.733, 95% CI: 0.589-0.912, Conclusion: Higher serum 25(OH)D levels are associated with a lower prevalence of OAB in females. Concordant observational and genetic evidence suggests a potential protective role of vitamin D, with systemic inflammation potentially modulating this association.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.