SynthesisFrontiers in nutrition2026
The triglyceride glucose-body mass index and the risk of gestational diabetes mellitus: a systematic review and meta-analysis.
Synthesis in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This study aimed to systematically evaluate the association of triglyceride-glucose body mass index (TyG-BMI) with the risk of gestational diabetes mellitus (GDM). Methods: A systematic search was conducted in PubMed, Embase, Web of Science, the Cochrane Library, China National Knowledge Infrastructure, Wanfang Data, and Chinese Science and Technology Journal Database from inception to 31 March 2026 for cohort studies investigating the association between TyG-BMI and GDM risk. Two reviewers independently conducted literature screening, data extraction and study quality assessment using the Newcastle-Ottawa Scale (NOS). Meta-analysis was performed with Stata 16.0 for heterogeneity test, sensitivity analysis and publication bias assessment, and Review Manager 5.4.1 for effect size pooling and subgroup analyses. Heterogeneity across studies was assessed using the Cochrane Q-test and Results: This meta-analysis included a total of 6 cohort studies with 52,877 participants. The overall pooled OR was 2.13 (95% CI: 1.26-3.61, Conclusions: This exploratory meta-analysis suggests that increased early-pregnancy TyG-BMI was significantly associated with a higher risk of GDM. TyG-BMI may serve as a potential early predictive biomarker for GDM, although further large-scale prospective studies are warranted to validate these results and identify potential effect modifiers. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD420261291099, identifier: CRD420261291099.
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