ReviewFrontiers in immunology2026
Multifaceted regulation of thymic tolerance by pattern recognition cascades.
Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Reprogramming immunometabolism: linking nutrient sensing, cell death, and therapeutic innovation.Immunologic research · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During their development, progenitor T cells have to pass through a series of tolerogenic filters inside the thymus, which ensure the survival and developmental advancement of only those thymocytes which fruitfully recognize the host's own MHCs conjugated with non-self antigenic peptides. A set of microbial and host-derived biomolecules, called 'patterns', dynamically regulates the proficiency of this thymopoietic axis by a combination of thymocyte-extrinsic antigen presentation and thymocyte-intrinsic TCR signalling. Although well-characterized in terms of their impact on peripheral T cell tolerance, there is a lack of clarity regarding the influence of these patterns on the thymic tolerogenic checkpoints. From a clinical angle, this stands as a formidable weak point for the widely used immunosuppressive therapies against autoimmunity, which generically target these pattern recognition cascades. This review explores different aspects of the pattern recognition receptor-mediated regulation of key thymic events from an exclusively tolerogenic perspective, and unravels the mechanistic complexity underlying their impact on thymic tolerance. As the pattern recognition-mediated signalling cascades constitute a significant branch of the inflammatory network, inferences from this review elaborate a frequently overlooked collaboration between inflammation and self-tolerance; highlighting the need for potential therapeutic repurposing against autoimmune diseases.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.