Evidence map›Paper›PMID 42345381›Full record

ArticleeLife2026

SynaptoTagMe, a toolkit for in vivo mapping and modulating neurotransmission at single-cell resolution.

Andrea Cuentas-Condori, Patricia Chanabá-López, Matthew Thomas, Likui Feng, Aaron Wolfe, Peter Agoba, Matthew L Schwartz, Maximillian Brown, Margaret S Ebert, Erik Jorgensen and 2 more

Abstract read
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Andrea Cuentas-CondoriDepartment of Neuroscience and Department of Cell Biology, Yale University School of Medicine, New Haven, United States.ORCID https://orcid.org/0000-0002-4847-0031
Patricia Chanabá-LópezDepartment of Neuroscience and Department of Cell Biology, Yale University School of Medicine, New Haven, United States.ORCID https://orcid.org/0009-0000-1510-2542
Matthew ThomasDepartment of Neuroscience and Department of Cell Biology, Yale University School of Medicine, New Haven, United States.ORCID https://orcid.org/0009-0005-0251-9150
Likui FengLulu and Anthony Wang Laboratory of Neural Circuits and Behavior, The Rockefeller University, New York, United States.
Aaron WolfeDepartment of Neuroscience and Department of Cell Biology, Yale University School of Medicine, New Haven, United States.
Peter AgobaDepartment of Neuroscience and Department of Cell Biology, Yale University School of Medicine, New Haven, United States.
Matthew L SchwartzHoward Hughes Medical Institute and School of Biological Sciences, University of Utah, Salt Lake City, United States.
Maximillian BrownLulu and Anthony Wang Laboratory of Neural Circuits and Behavior, The Rockefeller University, New York, United States.
Margaret S EbertLulu and Anthony Wang Laboratory of Neural Circuits and Behavior, The Rockefeller University, New York, United States.
Erik JorgensenHoward Hughes Medical Institute and School of Biological Sciences, University of Utah, Salt Lake City, United States.
Cornelia I BargmannLulu and Anthony Wang Laboratory of Neural Circuits and Behavior, The Rockefeller University, New York, United States.ORCID https://orcid.org/0000-0002-8484-0618
Daniel A Colón-RamosDepartment of Neuroscience and Department of Cell Biology, Yale University School of Medicine, New Haven, United States.ORCID https://orcid.org/0000-0003-0223-7717

Funding

SYNAPTIC FUNCTION IN THE NEMATODE C. ELEGANSR01NS034307 · NINDS · UNIVERSITY OF UTAH · PI JORGENSEN, ERIK M · 1995 to 2024
$5.8M
Examination of the cell biology of the synapse and behaviorR35NS132156 · NINDS · YALE UNIVERSITY · PI DANIEL A COLON-RAMOS · 2023 to 2026
$4.6M
Cellular and molecular mechanisms that temporally and spatially restrict synapticR01NS076558 · NINDS · YALE UNIVERSITY · PI COLON-RAMOS, DANIEL A · 2012 to 2022
$4.1M
Engineering the C. Elegans GenomeR01GM095817 · NIGMS · UNIVERSITY OF UTAH · PI JORGENSEN, ERIK M · 2011 to 2021
$2.8M
Adaptive glycolysis as a regulator of neuronal function and declineK99AG083129 · NIA · YALE UNIVERSITY · PI WOLFE, AARON · 2023 to 2024
$252k
Toward a library of balanced neuronal gene knockouts in C. elegansF32GM133139 · NIGMS · UNIVERSITY OF UTAH · PI RICH, MATTHEW SAUL · 2019 to 2020
$127k
Howard Hughes Medical Institute GT15993Jane Coffin Childs Memorial Fund for Medical Research AWD0006564NIH HHS F32GM133139NIH HHS K99AG083129NIH HHS R01 GM095817NIH HHS R01NS034307NIH HHS R01NS076558NIH HHS R35NS132156Pew Charitable Trusts AWD0006561
6 · The paper itself

Abstract

Understanding the organization and regulation of neurotransmission at the level of individual neurons and synapses requires tools that can track and manipulate transmitter-specific vesicles in vivo. Here, we present SynaptoTagMe, a suite of genetic tools in

Indexed as

Caenorhabditis elegansSingle-Cell AnalysisSynaptic TransmissionSynaptotagminsAnimalsNeuronsNeurotransmitter AgentsSynaptic VesiclesNeurotransmitter AgentsSynaptotagminsC. elegansco-transmissionmonoaminesneuroscienceneurotransmitterssynaptic terminalssynaptic vesicle transporter

Identifiers

PMID42345381
PMCPMC13299628

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.