ReviewBiology2026
Transcriptional Bursting in Pluripotent Stem Cells.
Review in Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Transcriptional bursting, the stochastic production of mRNA in episodic pulses, is a fundamental source of cell-to-cell heterogeneity. In pluripotent stem cells (PSCs), these bursting dynamics at core pluripotency loci are not just noise but critical determinants of identity maintenance and lineage commitment. This review synthesizes current quantitative frameworks for dissecting bursting kinetics and elaborates on the multilayered regulatory hierarchy that governs them, ranging from promoter-intrinsic features and 3D genome architecture to the formation of transcriptional condensates via liquid-liquid phase separation (LLPS). By integrating findings from genomic profiling and live-cell imaging, we highlight how the integrated action between super-enhancers and epigenetic states shapes the unique bursting dynamics in PSCs. Furthermore, we explore the functional consequences of these kinetics in pluripotency surveillance and cell fate decisions. Collectively, this review establishes a unified regulatory framework, providing novel insights for understanding stem cell heterogeneity and offering key insights for regenerative medicine.
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Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.