Evidence map›Paper›PMID 42345843›Full record

ArticleClocks & sleep2026

Hyperuricemia as a Biomarker for Circadian Syndrome: A Cross-Sectional Study.

Joud AlBashtawi, Hana Zeidan, Abdulrahman Al-Tairi, Najlaa Al-Marri, Mohammed Abdel Hamid, Reem Odaiba, Shaikha Al-Kurbi, Ramez Jaradat, Susu M Zughaier, Habib H Farooqui

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Article in Clocks & sleep, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Joud AlBashtawiCollege of Medicine, QU Health, Qatar University, Doha P.O. Box 2713, Qatar.ORCID 0009-0008-8135-0745
Hana ZeidanCollege of Medicine, QU Health, Qatar University, Doha P.O. Box 2713, Qatar.
Abdulrahman Al-TairiCollege of Medicine, QU Health, Qatar University, Doha P.O. Box 2713, Qatar.
Najlaa Al-MarriCollege of Medicine, QU Health, Qatar University, Doha P.O. Box 2713, Qatar.
Mohammed Abdel HamidCollege of Medicine, QU Health, Qatar University, Doha P.O. Box 2713, Qatar.
Reem OdaibaCollege of Medicine, QU Health, Qatar University, Doha P.O. Box 2713, Qatar.
Shaikha Al-KurbiCollege of Medicine, QU Health, Qatar University, Doha P.O. Box 2713, Qatar.
Ramez JaradatCollege of Medicine, QU Health, Qatar University, Doha P.O. Box 2713, Qatar.
Susu M ZughaierDepartment of Basic Medical Sciences, College of Medicine, QU Health, Qatar University, Doha P.O. Box 2713, Qatar.ORCID 0000-0001-7487-8770
Habib H FarooquiDepartment of Population Medicine, College of Medicine, QU Health, Qatar University, Doha P.O. Box 2713, Qatar.ORCID 0000-0002-3081-2929

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circadian Syndrome (CircS) links metabolic, behavioral, and mental health challenges to disrupted circadian rhythm. Hyperuricemia (HUA) is associated with cardiometabolic disorders; however, its connection to CircS remains incompletely understood. This study aims to determine if HUA can serve as a biomarker for CircS. We analyzed the National Health and Nutrition Examination Survey (NHANES) data (2005-2020) from 27,410 adults. CircS was defined as the presence of at least five out of eight components, encompassing the traditional metabolic syndrome criteria plus three additional factors: short sleep duration, depression, and non-alcoholic fatty liver disease (NAFLD). HUA was set at serum uric acid levels >6 mg/dL (357 µmol/L) for females and >7 mg/dL (416 µmol/L) for males. Multivariable logistic regression identified predictors of CircS, and dose-response relationships were explored. Of 27,410 participants, 2076 (7.57%) had CircS. HUA was found to be the strongest independent predictor of CircS, with an odds ratio (OR) of 3.26 (95% uncertainty interval (UI) 2.80-3.80,

Indexed as

circadian syndromehyperuricemiametabolic syndrome

Identifiers

PMID42345843
PMCPMC13297815

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.