SynthesisBiosensors2026
Ion-Selective Sensors for Orthopaedic Applications: A Systematic Review.
Synthesis in Biosensors, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sensors are an established driver of diagnostics and prevention in the medical field, including orthopaedics. Today, the subclass of ion-selective sensors (ISSs) is on the leading edge due to its advantages, enabled by technological advancements in manufacturing, such as miniaturization, precision, accuracy, specificity, a wide measuring scale, ease of use, flexible operating conditions, and measuring speed. While ISSs' impact on environmental and health fields is already the subject of investigation, it still needs to be analysed specifically in orthopaedics, which is the aim of this Review. A PubMed and Scopus search was performed using the keywords "ion", "sensor", "electrodes", "selective", "musculoskeletal", "implant", "joint replacement", and "orthopaedic"; after systematic screening, 44 studies were included in the synthesis. First, studies were classified based on the target ion. Only a few papers treated applications specifically in orthopaedics, confirming that ISSs are still largely an unexplored frontier here. However, all of the studies targeted ions with a role also in musculoskeletal pathophysiology, thus relative ISSs could have a potential impact on orthopaedic diagnosis and treatment. Then, when described by the papers, ISSs' technological solutions were systematically evaluated. Finally, the main ISSs development targets for reaching orthopaedic clinical application were highlighted, including biocompatibility (e.g., implantability), long-term stability, calibration, and validation. Overcoming these challenges will enable ISSs to progress from laboratory prototypes to clinically viable tools, supporting the advancement of next-generation sensorised prostheses, fixation devices, and surgical instruments, and paving the way for predictive and personalised orthopaedic medicine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.