Dexmedetomidine Preserves Hippocampal Neurogenesis During Recovery from Neonatal Hyperoxia in Rats.

Stefanie Endesfelder, Christoph Bührer, Thomas Schmitz

Abstract read

In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Stefanie EndesfelderDepartment of Neonatology, Charité-University Medical Center Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.ORCID 0000-0002-4030-7969

Christoph BührerDepartment of Neonatology, Charité-University Medical Center Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.ORCID 0000-0002-9950-414X

Thomas SchmitzClinic for Pediatrics and Adolescent Medicine, University Hospital of the Brandenburg Medical School, Fehrbelliner Straße 38, 16816 Neuruppin, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neonatal hyperoxia induces oxidative stress that disrupts neurodevelopmental processes. While dexmedetomidine (DEX) exhibits acute neuroprotective properties, its long-term impact on developmental trajectories during recovery remains incompletely understood. This study examined whether a single neonatal dose of DEX modulates hippocampal neurogenesis following hyperoxia across defined postnatal stages. Six-day-old

Indexed as

DexmedetomidineHippocampusHyperoxiaNeurogenesisAnimalsAnimals, NewbornApoptosisAutophagyMaleNeuroprotective AgentsOxidative StressRatsRats, WistarDexmedetomidineNeuroprotective Agentsapoptosisautophagydexmedetomidinehippocampal neurogenesisneonatal hyperoxianeurodevelopmental dysmaturationoxidative stress

Identifiers

PMID42346121

DOI10.3390/cells15121094

PMCPMC13297234

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.