Evidence map›Paper›PMID 42346199›Full record

ArticleClinics and practice2026

Post-Levothyroxine Thyroid Dysfunction in Saudi Arabian Patients with Hypothyroidism: A Cross-Sectional Study.

Baraah Ghssan AlHassan, Maujid Masood Malik, Ahmed Mohamedain, Adnan Jehangir, Farhana Ayub, Omer Musa, Ahmed Ibrahim, Habib Ahmad Qureshi, Hayder A Giha

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Article in Clinics and practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Baraah Ghssan AlHassanDepartment of Biomedical Sciences, College of Medicine, King Faisal University, Al-Ahsa P.O. Box 400, Saudi Arabia.
Maujid Masood MalikDepartment of Biomedical Sciences, College of Medicine, King Faisal University, Al-Ahsa P.O. Box 400, Saudi Arabia.ORCID 0000-0002-6559-9742
Ahmed MohamedainDepartment of Biomedical Sciences, College of Medicine, King Faisal University, Al-Ahsa P.O. Box 400, Saudi Arabia.
Adnan JehangirDepartment of Biomedical Sciences, College of Medicine, King Faisal University, Al-Ahsa P.O. Box 400, Saudi Arabia.ORCID 0009-0008-6819-4688
Farhana AyubDepartment of Biomedical Sciences, College of Medicine, King Faisal University, Al-Ahsa P.O. Box 400, Saudi Arabia.
Omer MusaDepartment of Biomedical Sciences, College of Medicine, King Faisal University, Al-Ahsa P.O. Box 400, Saudi Arabia.ORCID 0000-0003-1435-3774
Ahmed IbrahimDepartment of Public Health, College of Applied Medical Sciences, King Faisal University, Al-Ahsa 31982, Saudi Arabia.ORCID 0000-0002-6516-5450
Habib Ahmad QureshiMohammed Al-Mana College for Medical Sciences, Al Khobar 34222, Saudi Arabia.ORCID 0000-0001-8751-495X
Hayder A GihaCentre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPost-thyroxine treatment of thyroid dysfunction remains a clinical concern, especially in Middle Eastern populations.

methodsThis descriptive cross-sectional study was conducted in 2023 at King Fahad Hospital, Hufof, Kingdom of Saudi Arabia. Of the 237 patients treated with L-thyroxine (L-T4) for hypothyroidism, 163 patients, almost exclusively females (152 females, 11 males), met the inclusion criteria and were enrolled. Thyroid hormones, lipid profiles, and 25-hydroxyvitamin D (25OH-D) were measured using standard laboratory assays.

resultsOnly 57% of patients achieved euthyroid status following L-T4 treatment, while 12.3% developed post-thyroxine-treatment (PTT) hyperthyroidism, and 30.7% developed PTT hypothyroidism. Older age was significantly associated with dysthyroidism (

conclusionsThe proportions of patients with PTT hypo- and hyperthyroidism are aligned with international observations. Furthermore, the age was significantly associated with dysthyroidism, and dyslipidemia is the most consistent biochemical correlate of suboptimal thyroid status; however, the associations of PTT dysthyroidism with hypovitaminosis D and BMI were not noticed in this setting.

Indexed as

dyslipidemiahypothyroidismL-T4obesitythyroid stimulating hormonevitamin D

Identifiers

PMID42346199
PMCPMC13298025

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