Evidence map›Paper›PMID 42346294›Full record

ArticleDiseases (Basel, Switzerland)2026

Folate Receptor Alpha Autoantibodies in Vector-Borne Disease Populations.

Lindsey Wells, Myriah Hinchey, Richard E Frye, Amelia Morgan

Abstract read
In one paragraph

Article in Diseases (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lindsey WellsAutism Discovery and Treatment Foundation, Phoenix, AZ 85050, USA.
Myriah HincheyAutism Discovery and Treatment Foundation, Phoenix, AZ 85050, USA.
Richard E FryeAutism Discovery and Treatment Foundation, Phoenix, AZ 85050, USA.ORCID 0000-0003-4442-2937
Amelia MorganAutism Discovery and Treatment Foundation, Phoenix, AZ 85050, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVector-borne diseases (VBDs) caused by

methodsThis retrospective cohort study included 68 VBD-positive patients with and without PANS evaluated at a single clinical practice. VBD testing was performed by IGeneX Laboratories; FRAA analysis including binding, blocking, and soluble folate receptor (sFR) testing was performed by Religen Laboratories (Plymouth Meeting, PA). Statistical associations were assessed using Fisher's exact test with Wilson 95% confidence intervals.

resultsOf the 68 VBD-positive patients, 42 (61.8%; 95% CI: 49.9-72.4%) were also FRAA-positive. Soluble folate receptor (sFR) was detected in eight patients (11.8%; 95% CI: 6.1-21.5%), all of whom were binding FRAA-positive, with 87.5% carrying confirmed evidence of

conclusionsThis study demonstrates a high prevalence of FRAA in a pediatric VBD cohort. The sFR was strongly associated with

Indexed as

folate receptor alphafolate receptor alpha autoantibodiesleucovorinpediatric acute-onset neuropsychiatric syndrome (PANS)vector-borne diseases

Identifiers

PMID42346294
PMCPMC13298303

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.