Evidence map›Paper›PMID 42346443›Full record

ArticleJournal of cardiovascular development and disease2026

Myocarditis Prognostic Score: A New Risk Assessment Tool.

Daniela Di Lisi, Cristina Madaudo, Francesca Macaione, Francesca Castro, Francesco Bongiorno, Francesco Stabile, Andrea Micarelli, Alfredo Ruggero Galassi, Giuseppina Novo

Abstract read
In one paragraph

Article in Journal of cardiovascular development and disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Daniela Di LisiDivision of Cardiology, University Hospital Paolo Giaccone, 90127 Palermo, Italy.ORCID 0000-0003-4510-6805
Cristina MadaudoDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE) "G. D'Alessandro", University of Palermo, 90133 Palermo, Italy.ORCID 0000-0002-9151-4335
Francesca MacaioneDivision of Cardiology, University Hospital Paolo Giaccone, 90127 Palermo, Italy.
Francesca CastroDivision of Cardiology, University Hospital Paolo Giaccone, 90127 Palermo, Italy.
Francesco BongiornoDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE) "G. D'Alessandro", University of Palermo, 90133 Palermo, Italy.
Francesco StabileDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE) "G. D'Alessandro", University of Palermo, 90133 Palermo, Italy.
Andrea MicarelliDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE) "G. D'Alessandro", University of Palermo, 90133 Palermo, Italy.
Alfredo Ruggero GalassiDivision of Cardiology, University Hospital Paolo Giaccone, 90127 Palermo, Italy.
Giuseppina NovoDivision of Cardiology, University Hospital Paolo Giaccone, 90127 Palermo, Italy.ORCID 0000-0003-2127-7351

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMyocarditis is an inflammatory disease of the myocardium with multiple causes and evolutions. The aim of our study was to design a prognostic multiparametric score in patients with myocarditis, to identify those at higher risk of cardiovascular outcomes.

methodsA prospective study was performed enrolling 98 patients with myocarditis: 72 M, 26 F; median age 27 [IQR 20-40]. Patients were divided into two groups: complicated (CM) and uncomplicated myocarditis (UM). Six months after hospital admission, cardiac magnetic resonance (CMR) and cardiological consultation were repeated. Cardiovascular outcomes (death, hospitalization for heart failure, heart transplant, ICD implantation, and heart failure development) were evaluated at 6 months and after 3 years.

resultsWe found 67 UM and 31 CM. Cardiovascular outcomes were significantly higher in patients with CM. We found a significant correlation between cardiovascular outcomes and reduced LVEF at hospital admission, reduced global longitudinal strain in absolute values, septal late gadolinium enhancement (LGE) at CMR, longer persistence time of increased troponin, LGE extension progression or persistence at 6 months of CMR. A myocarditis prognostic score was developed. A score ≥ 5 showed higher sensitivity (100%) and specificity (87%)-AUC 1, to identify cardiovascular outcomes in patients with myocarditis. A score between 3 and 4 showed high sensitivity but low specificity. A score ≤ 2 was associated with low probability of cardiovascular outcomes.

conclusionOur study confirms the high probability of cardiovascular outcomes in patients with CM and it suggests a myocarditis prognostic score to identify patients at higher risk of cardiovascular outcomes.

Indexed as

cardiac magnetic resonancemyocarditisprognosisscore

Identifiers

PMID42346443
PMCPMC13300360

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.