Evidence map›Paper›PMID 42346449›Full record

ReviewJournal of cardiovascular development and disease2026

Advances in Reperfusion Therapy and Cytoprotection for Acute Ischemic Stroke.

Zihan Li, Chunjuan Wang

Abstract readReview
In one paragraph

Review in Journal of cardiovascular development and disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Zihan LiDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100069, China.
Chunjuan WangChina National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing 100069, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stroke is one of the leading causes of disability and mortality worldwide, and approximately 87% of cases are acute ischemic stroke (AIS). For patients with AIS, rapid administration of reperfusion therapy within the therapeutic time window remains the most effective treatment strategy. Over the past decade, numerous high-quality clinical trials have driven rapid advances in treatment strategies. Meanwhile, increasing attention has been directed toward cytoprotective therapies aimed at mitigating ischemic and reperfusion-related brain injury, which may act synergistically with reperfusion strategies. Although many related clinical trials have failed to demonstrate clear clinical benefit, they have provided valuable insights for the development of future cytoprotective agents. This review focuses on recent advances and remaining challenges in reperfusion therapy and cytoprotection for AIS.

Indexed as

acute ischemic strokecytoprotective agentsreperfusion therapyreviewthrombectomythrombolysis

Identifiers

PMID42346449
PMCPMC13301152

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.