Evidence map›Paper›PMID 42346845›Full record

ArticleMedical sciences (Basel, Switzerland)2026

Risk of Long-Term Clozapine Medication over Decades for Cardiac Adverse Events Including Heart Failure and Its Pathophysiology: A Japan and China Retrospective Cohort Analysis.

Ruri Okubo, Nobutomo Yamamoto, Xiaojun Shao, Taku Omori, Jian Xiong, Changhui Liu, Ryo Kato, Masahiko Murata, Tetsuji Kitano, Yuki Ito and 6 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Medical sciences (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Ruri OkuboDepartment of Neuropsychiatry, Division of Neuroscience, Graduate School of Medicine, Mie University, Tsu 514-8507, Japan.
Nobutomo YamamotoDepartment of Neuropsychiatry, Division of Neuroscience, Graduate School of Medicine, Mie University, Tsu 514-8507, Japan.
Xiaojun ShaoDepartment of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang 110001, China.
Taku OmoriDepartment of Cardiology and Nephrology, Graduate School of Medicine, Mie University, Tsu 514-8507, Japan.
Jian XiongDepartment of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang 110001, China.
Changhui LiuDepartment of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang 110001, China.
Ryo KatoDepartment of Neuropsychiatry, Division of Neuroscience, Graduate School of Medicine, Mie University, Tsu 514-8507, Japan.
Masahiko MurataDepartment of Neuropsychiatry, Division of Neuroscience, Graduate School of Medicine, Mie University, Tsu 514-8507, Japan.
Tetsuji KitanoDepartment of Cardiology and Nephrology, Graduate School of Medicine, Mie University, Tsu 514-8507, Japan.ORCID 0000-0002-8539-5907
Yuki ItoDepartment of Neuropsychiatry, Division of Neuroscience, Graduate School of Medicine, Mie University, Tsu 514-8507, Japan.
Tomoka OkaDepartment of Neuropsychiatry, Division of Neuroscience, Graduate School of Medicine, Mie University, Tsu 514-8507, Japan.
Toshiaki OnitsukaDepartment of Neuropsychiatry, Division of Neuroscience, Graduate School of Medicine, Mie University, Tsu 514-8507, Japan.
Eishi MotomuraDepartment of Neuropsychiatry, Division of Neuroscience, Graduate School of Medicine, Mie University, Tsu 514-8507, Japan.ORCID 0000-0003-3013-9284
Kaoru DohiDepartment of Cardiology and Nephrology, Graduate School of Medicine, Mie University, Tsu 514-8507, Japan.ORCID 0000-0002-5078-6326
Gang ZhuDepartment of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang 110001, China.
Motohiro OkadaDepartment of Neuropsychiatry, Division of Neuroscience, Graduate School of Medicine, Mie University, Tsu 514-8507, Japan.ORCID 0000-0002-9025-2548

Funding

Japan Society for the Promotion of Science 24K10730Major Project of the Department of Science and Technology of Liaoning Province 2024JH2/102600305
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Antipsychotic AgentsClozapineHeart FailureAdultChinaFemaleHumansJapanMaleMiddle AgedNatriuretic Peptide, BrainRetrospective StudiesRisk FactorsSchizophreniaAntipsychotic AgentsClozapineNatriuretic Peptide, BrainChinaclozapineejection fractionheart failureJapanlong-term medication

Identifiers

PMID42346845
PMCPMC13302769

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.