ReviewMedical sciences (Basel, Switzerland)2026
Spatial Immunology in Translation: Linking Immune Organisation to Therapeutic Outcome.
Review in Medical sciences (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immune-targeted therapies are commonly interpreted through molecular and cell-centric frameworks that insufficiently capture how immune activity is organised within intact tissues. This limitation complicates translational interpretation of therapeutic efficacy and response variability when inflammatory activity is spatially structured within diseased tissue. This review examines immune organisation as a relevant dimension of immune function and frames interaction-defined immune environments as functional units of inflammation. It outlines how cellular composition, tissue compartmentalisation, and persistence of interaction environments shape where immune signalling is concentrated and sustained in situ. By linking immune organisation to tissue-level behaviour, the review provides translational context for interpreting target engagement and therapeutic effects, supporting more informed alignment between therapeutic strategies and the immune architectures that dominate disease activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.