Evidence map›Paper›PMID 42347149›Full record

ReviewProteomes2026

Systematic Review of Protein Signatures for Clinical Monitoring of Osteonecrosis of the Jaw: Meta-Analysis and Insights from Bioinformatics-Driven Proteomics.

Helena Oliveira Deróbio, Isabela Dos Reis Souza, François Isnaldo Dias Caldeira, Fernanda Gonçalves Basso, Taisa Nogueira Pansani

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Proteomes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Helena Oliveira DeróbioDepartment of Dental Materials and Prosthodontics, School of Dentistry, São Paulo State University (UNESP), Humaitá Street, 1680, Araraquara 14801-903, SP, Brazil.
Isabela Dos Reis SouzaDepartment of Dental Materials and Prosthodontics, School of Dentistry, São Paulo State University (UNESP), Humaitá Street, 1680, Araraquara 14801-903, SP, Brazil.
François Isnaldo Dias CaldeiraDepartment of Morphology and Pediatric Dentistry, School of Dentistry, São Paulo State University (UNESP), Humaitá Street, 1680, Araraquara 14801-903, SP, Brazil.
Fernanda Gonçalves BassoDepartment of Physiology and Pathology, School of Dentistry, São Paulo State University (UNESP), Humaitá Street, 1680, Araraquara 14801-903, SP, Brazil.
Taisa Nogueira PansaniDepartment of Dental Materials and Prosthodontics, School of Dentistry, São Paulo State University (UNESP), Humaitá Street, 1680, Araraquara 14801-903, SP, Brazil.ORCID 0000-0002-5931-6849

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 2022/06491-5Fundação de Amparo à Pesquisa do Estado de São Paulo 2024/00745-0Fundação de Amparo à Pesquisa do Estado de São Paulo 2024/10548-8Fundação de Amparo à Pesquisa do Estado de São Paulo 2024/15353-0
6 · The paper itself

Abstract

backgroundSeveral studies have investigated the clinical and immunological aspects of medication-related osteonecrosis of the jaw (MRONJ). However, the underlying immunological mechanisms and signaling pathways involved in its pathophysiology remain incompletely understood. This systematic review and meta-analysis, complemented by bioinformatics analyses, aimed to identify proteomic biomarkers associated with MRONJ.

methodsSix databases (PubMed, Embase, Scopus, Web of Science, Cochrane Library, and VHL) were searched, along with gray literature and manual searches. Observational studies in English comparing proteomic profiles of individuals with and without MRONJ were included. Study selection and data management were conducted using EndNote™ X8 and Rayyan.ai, and risk of bias was assessed using the QUADOMICS tool. Functional enrichment analysis was performed using g:Profiler and Reactome, and interaction networks were constructed using GeneMANIA, STRING, and MetaboAnalyst (Cytoscape program; version 3.10.1). Meta-analysis was performed in RStudio (R-4.5, Rstudio extension 2025.05.1+513) (α = 0.05).

resultsThree studies were included in the review, and two in the meta-analysis. The meta-analysis showed higher salivary levels of Apolipoprotein B-100 (APOB), Apolipoprotein A-II (APOA2), and Heparin Cofactor 2 (SERPIND1) in MRONJ patients, while the protein Keratin (KRT16) showed reduced levels without statistical significance. Bioinformatics analyses indicated involvement in lipid metabolism, impaired tissue repair, and inflammatory and immune responses.

conclusionsThese findings suggest altered salivary proteomic signatures in MRONJ for APOB, APOA2, SERPIND1, and KRT16 proteins.

Indexed as

bisphosphonatesosteonecrosisproteome

Identifiers

PMID42347149
PMCPMC13306536

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.