Evidence map›Paper›PMID 42347260›Full record

ArticlePathogens (Basel, Switzerland)2026

HPV-16 E6 and E7 Oncoproteins Promote Cell Proliferation and Migration Through the miR-218-5p/

Brayan Villazana-Calderon, Hilda Jiménez-Wences, J Noé García-Chávez, Imelda Martínez-Ramírez, Claudia González-Espinosa, Gloria Fernández-Tilapa, Marcela Lizano, J Omar Muñoz-Bello

Abstract read
In one paragraph

Article in Pathogens (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Brayan Villazana-CalderonSubdirección de Investigación Básica, Instituto Nacional de Cancerología, Mexico City 14080, Mexico.
Hilda Jiménez-WencesFacultad de Ciencias Químico-Biológicas, Universidad Autónoma de Guerrero, Chilpancingo 39090, Mexico.
J Noé García-ChávezTecnológico Nacional de México/ITS de Irapuato, Irapuato 36821, Mexico.ORCID 0000-0003-4482-1575
Imelda Martínez-RamírezSubdirección de Investigación Básica, Instituto Nacional de Cancerología, Mexico City 14080, Mexico.
Claudia González-EspinosaDepartamento de Farmacobiología, Centro de Investigación y de Estudios Avanzados, Unidad Sede Sur, Mexico City 14330, Mexico.ORCID 0000-0001-7332-3829
Gloria Fernández-TilapaFacultad de Ciencias Químico-Biológicas, Universidad Autónoma de Guerrero, Chilpancingo 39090, Mexico.ORCID 0000-0002-3737-2399
Marcela LizanoSubdirección de Investigación Básica, Instituto Nacional de Cancerología, Mexico City 14080, Mexico.ORCID 0000-0002-7553-2541
J Omar Muñoz-BelloSubdirección de Investigación Básica, Instituto Nacional de Cancerología, Mexico City 14080, Mexico.ORCID 0000-0002-6809-0212

Funding

Instituto Nacional de Cancerología (024/019/IBI)(CEI/025/24)Secretaría de Ciencia Tecnología e Innovación A1-S-43684Universidad Nacional Autónoma de México IN208924
6 · The paper itself

Abstract

The continuous expression of HPV oncogenes E6 and E7 contributes to the maintenance of the cervical cancer (CC) phenotype by altering gene expression programs involved in tumor progression and aggressiveness. MicroRNAs (miRNAs) have emerged as critical regulators of gene expression in CC, including miR-218-5p, which has been described as a tumor suppressor. In this study, we investigated the impact of HPV-16 oncoproteins E6 and E7 on the regulation of miR-218-5p expression and its target gene

Indexed as

Human papillomavirus 16MicroRNAsOncogene Proteins, ViralPapillomavirus E7 ProteinsPapillomavirus InfectionsPhosphatidylinositol 3-KinasesRepressor ProteinsUterine Cervical NeoplasmsCell Line, TumorCell MovementCell ProliferationFemaleGene Expression Regulation, NeoplasticHumansE6 protein, Human papillomavirus type 16MicroRNAsMIRN218 microRNA, humanoncogene protein E7, Human papillomavirus type 16Oncogene Proteins, ViralPapillomavirus E7 ProteinsPhosphatidylinositol 3-KinasesRepressor Proteinscervical cancerE6 and E7HPV oncoproteinsmiR-218-5pPIK3C2A

Identifiers

PMID42347260
PMCPMC13305930

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.