Evidence map›Paper›PMID 42347393›Full record

ArticleToxics2026

Plasma or Serum? A Pilot Evaluation of Matrix Selection for Integrated Metabolomics and Exposomics of Clinical Samples.

Xiaowen Ji, Julian Edwards, Miaomiao Wang, Juan C Irwin, Binya Liu, Amanda M Gutierrez, Lin Li, Jeannette C Lager, Camran R Nezhat, David K Stevenson and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Xiaowen JiEnvironmental Chemistry Laboratory, Department of Toxic Substances Control, California Environmental Protection Agency, Berkeley, CA 94710, USA.ORCID 0000-0002-0507-7520
Julian EdwardsEnvironmental Chemistry Laboratory, Department of Toxic Substances Control, California Environmental Protection Agency, Berkeley, CA 94710, USA.
Miaomiao WangEnvironmental Chemistry Laboratory, Department of Toxic Substances Control, California Environmental Protection Agency, Berkeley, CA 94710, USA.
Juan C IrwinDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco (UCSF), San Francisco, CA 94143, USA.ORCID 0000-0002-5647-4331
Binya LiuDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco (UCSF), San Francisco, CA 94143, USA.
Amanda M GutierrezDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco (UCSF), San Francisco, CA 94143, USA.
Lin LiDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco (UCSF), San Francisco, CA 94143, USA.
Jeannette C LagerDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco (UCSF), San Francisco, CA 94143, USA.
Camran R NezhatCamran Nezhat Institute, Woodside, CA 94061, USA.
David K StevensonDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA.
Tomiko T OskotskyBakar Computational Health Sciences Institute, University of California San Francisco (UCSF), San Francisco, CA 94158, USA.ORCID 0000-0001-7393-5120
Marina SirotaBakar Computational Health Sciences Institute, University of California San Francisco (UCSF), San Francisco, CA 94158, USA.ORCID 0000-0002-7246-6083
Dimitri AbrahamssonDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco (UCSF), San Francisco, CA 94143, USA.ORCID 0000-0002-3402-7565
Linda C GiudiceDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco (UCSF), San Francisco, CA 94143, USA.ORCID 0000-0002-1677-0822
Tracey J WoodruffDepartment of Epidemiology & Population Health, School of Medicine, Stanford University, Stanford, CA 94305, USA.
Joshua F RobinsonDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco (UCSF), San Francisco, CA 94143, USA.
June-Soo ParkEnvironmental Chemistry Laboratory, Department of Toxic Substances Control, California Environmental Protection Agency, Berkeley, CA 94710, USA.

Funding

NEXUS: Network for Exposomics in the U.S.U24ES036819 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Rima Habre, GARY W MILLER · 2024 to 2026
$4.6M
NIEHS NIH HHS U24 ES036819NIH HHS 1P01HD106414-04NIH HHS 1P30ES030284-09
6 · The paper itself

Abstract

Serum and plasma are the most widely used matrices in metabolomics and human biomonitoring studies; however, the optimal matrix for integrated non-targeted analysis (NTA) workflows combining metabolomics and exposomics has not been systematically evaluated. This pilot study applied parallel NTA workflows to paired serum and plasma samples from five individuals to characterize matrix-dependent differences and provide an empirical basis for matrix selection in integrated studies. Three analytical methods were employed: one metabolomic method (Method 1) using Hydrophilic Interaction Liquid Chromatography (HILIC) and Reversed-Phase Liquid Chromatography (RPLC) columns and one exposomics (Method 2) method using an RPLC column, each analyzed in both electrospray ionization (ESI) positive and negative modes. Overall, serum and plasma showed broad similarity, with substantial overlap in detected features and strong linear correlations between paired samples (R

Indexed as

exposomicsmatrix selectionmetabolomicsnon-targeted analysisplasmaserum

Identifiers

PMID42347393
PMCPMC13307841

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.