Charting the Path Forward for HIV Immune-Based Prevention: Contributions of the Division of AIDS at NIAID.

Julia Hutter, M Patricia D'Souza, Janet M McNicholl, James R Lane, Robert W Eisinger, Cesar Boggiano

Abstract read

In one paragraph

Article in Vaccines, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Julia HutterDivision of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

M Patricia D'SouzaDivision of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0001-6631-7615

Janet M McNichollDivision of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

James R LaneDivision of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Robert W EisingerDivision of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-0006-8772

Cesar BoggianoDivision of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-5503-8335

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This perspective outlines the ongoing necessity for an HIV vaccine and immune-based prevention strategies in an era of availability of multiple behavioral and pharmacological HIV prevention interventions, including safe and highly effective pre-exposure prophylaxis (PrEP). We describe the approach of the National Institute of Allergy and Infectious Diseases (NIAID), Division of AIDS (DAIDS), based on key scientific progress, critical steps, and persistent challenges in achieving broad and durable immune protection against HIV. We highlight DAIDS coordinated infrastructure, clinical trial networks, and partnerships that enable iterative development and de-risk innovation for these interventions. Finally, we consider implications for trial design and priorities for advancing scalable HIV immune-based prevention.

Indexed as

broadly neutralizing antibodies (bNAbs)germline-targeting immunogensHIV immunogen designHIV prevention researchHIV vaccineimmune-based preventionpre-exposure prophylaxis (PrEP)sequential immunizationvaccine clinical trials

Identifiers

PMID42347601

DOI10.3390/vaccines14060480

PMCPMC13307842

What Socratic holds

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.