Evidence map›Paper›PMID 42348090›Full record

ArticleEuropean journal of epidemiology2026

Adherence to the Mediterranean diet and risk of pancreatic cancer: an analysis of 2.3 million participants in the Pooling Project of Prospective Studies of Diet and Cancer (DCPP).

Qinting Shen, Claire Mobley, Molin Wang, Pietro Ferrari, Hans-Olov Adami, Nina Afshar, Ana Babic, Piet A van den Brandt, En Cheng, A Heather Eliassen and 43 more

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Article in European journal of epidemiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

53 authors.

Qinting ShenDepartment of Epidemiology, Columbia University Mailman School of Public Health, New York, NY, USA.
Claire MobleyDepartment of Epidemiology, Columbia University Mailman School of Public Health, New York, NY, USA.
Molin WangDepartment of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA, USA.
Pietro FerrariInternational Agency for Research on Cancer, World Health Organization, Lyon, France.
Hans-Olov AdamiDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.
Nina AfsharCancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia.
Ana BabicDepartment of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Piet A van den BrandtDepartment of Epidemiology, Maastricht University, Maastricht, The Netherlands.
En ChengDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.
A Heather EliassenDepartment of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA, USA.
Teresa T FungDepartment of Nutrition, Harvard TH Chan School of Public Health, Boston, MA, USA.
Edward L GiovannucciDepartment of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA, USA.
Mayo HirabayashiDivision of Prevention, National Cancer Center Institute for Cancer Control, Tokyo, Japan.
Tao HouDepartment of Nutrition, Harvard TH Chan School of Public Health, Boston, MA, USA.
Brian Z HuangDepartment of Population and Public Health Sciences, Keck School of Medicine of USC, Los Angeles, CA, USA.
Wen-Yi HuangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Corinne E JoshuDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Rieko KaneharaDivision of Cohort Research, National Cancer Center Institute for Cancer Control, Tokyo, Japan.
Verena KatzkeCancer Epidemiology, DKFZ German Cancer Research Center, Heidelberg, Germany.
James V LaceyDivision of Health Analytics, Department of Computational and Quantitative Medicine, City of Hope, Duarte, CA, USA.
Matthew J LandryDepartment of Population Health and Disease Prevention, University of California, Irvine, CA, USA.
Susanna C LarssonInstitute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden.
Linda M LiaoDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Maria Elena MartinezHerbert Wertheim School of Public Health, University of California at San Diego, La Jolla, CA, USA.
Marjorie L McCulloughDepartment of Population Science, American Cancer Society, Atlanta, GA, USA.
Anthony B MillerDalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
Roger L MilneCancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia.
Steven C MooreDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Lorelei A MucciDepartment of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA, USA.
Sabine NaudinCentre for research in Epidemiology and Population Health (CESP), University Paris Saclay (UPS), UVSQ, National Institute of Health and Medical Research (INSERM), Gustave Roussy, Villejuif, France.
Anna PrizmentDepartment of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN, USA.
Song-Yi ParkPopulation Sciences in the Pacific Program, University of Hawai'i Cancer Center, Honolulu, HI, USA.
Thomas E RohanDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.
Elio RiboliCancer Epidemiology and Prevention, School of Public Health, Imperial College, London, UK.
Kim RobienDepartment of Exercise and Nutrition Sciences, George Washington University, Washington, DC, USA.
Sven SandinDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.
Norie SawadaDivision of Cohort Research, National Cancer Center Institute for Cancer Control, Tokyo, Japan.
Marissa M Shams-WhiteDepartment of Population Science, American Cancer Society, Atlanta, GA, USA.
Rashmi SinhaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Karl Smith-ByrneCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Meir J StampferDepartment of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA, USA.
Rachael Z Stolzenberg-SolomonDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Caroline Y UmDepartment of Population Science, American Cancer Society, Atlanta, GA, USA.
Kala VisvanathanDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Sophia S WangDivision of Health Analytics, Department of Computational and Quantitative Medicine, City of Hope, Duarte, CA, USA.
Elisabete WeiderpassInternational Agency for Research on Cancer, World Health Organization, Lyon, France.
Emily WhiteFred Hutchinson Cancer Research Center, Seattle, WA, USA.
Walter C WillettDepartment of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA, USA.
Alicja WolkInstitute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden.
Brian M WolpinDepartment of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Chen YuanDepartment of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Stephanie A Smith-Warner *Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA, USA.
Jeanine M Genkinger *Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY, USA. jg3081@columbia.edu.ORCID http://orcid.org/0000-0002-8438-0412

Funding

American Institute for Cancer Research 359650NIAAA NIH HHS R01AA024770
6 · The paper itself

Abstract

Pancreatic cancer incidence is rising, yet few modifiable risk factors have been identified. The Mediterranean diet, which lowers inflammation and improves healthy weight maintenance and insulin control, may lower pancreatic cancer risk, yet the evidence for this association is inconsistent. To investigate the association, we conducted a pooled analysis of 2,315,406 individuals from 23 prospective cohorts in the Pooling Project of Prospective Studies of Diet and Cancer (DCPP), of whom 10,748 developed incident pancreatic cancer over a mean follow-up duration ranging from 8.1 to 23.3 years across studies. Adherence to the Mediterranean diet was assessed using the alternative Mediterranean diet score (aMED) and a modified score excluding alcohol (maMED). Study- and sex-specific hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using Cox proportional hazards models and then pooled using random effect models. No statistically significant association was found between aMED or maMED and pancreatic cancer or pancreatic ductal adenocarcinoma (PDAC) risk. For aMED, the pooled pancreatic cancer HR was 0.96 (95% CI: 0.90-1.02) comparing the fourth to the first quartile, 0.94 (0.88-1.00) comparing high (6-9) versus low (0-3) scores, and 0.98 (0.96-1.00) per 2-unit increment in the score. Overall, there was no evidence of heterogeneity in these associations by sex, attained age, race, BMI, physical activity, or follow-up time; a positive association between maMED and pancreatic cancer risk was observed in past smokers (HR = 1.04, 95% CI 1.00-1.09) but not in never or current smokers (P

Indexed as

Dietary patternsMediterranean dietPancreasPancreatic cancerPooled analysisPooling project

Identifiers

PMID42348090

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.