ArticleClinical rheumatology2026
Replacing stationary time or light physical activity with moderate-to-vigorous physical activity is associated with improved metabolic health in adults with or at risk of knee osteoarthritis.
Article in Clinical rheumatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundIndividuals with knee osteoarthritis are at an increased risk of poor metabolic health. We tested if cross-sectionally replacing stationary time with light or moderate-to-vigorous physical activity would be associated with lower odds of type 2 diabetes mellitus, abdominal circumference, and body mass index (BMI) in individuals with or at risk for knee osteoarthritis.
methodsParticipants (n = 1660, 55%female) from the Osteoarthritis Initiative were included. Physical activity was assessed using hip-worn accelerometers. Type 2 diabetes mellitus was self-reported and abdominal circumference and BMI were measured. Isotemporal substitution modeling estimated the impact of replacing stationary time with light or moderate-to-vigorous physical activity on metabolic health. Models were adjusted for age, sex, and radiographic knee osteoarthritis severity.
resultsThe mean age was 65 ± 9 years, and 74% had at least one metabolic deficit. Individuals spent 591 ± 89.2, 280 ± 77.1 and 18.5 ± 19.4 min/day in stationary, light and moderate-to-vigorous physical activity, respectively. Replacing 10-min per day of stationary time with moderate-to-vigorous physical activity was associated with lower odds of type 2 diabetes mellitus (OR = 0.80, p < 0.001), reduced abdominal circumference (β = - 1.26, p < 0.001) and BMI (β = - 0.45, p < 0.001). Similar results were observed when substituting light activity with moderate-to-vigorous physical activity. Replacing stationary time with light activity was not associated with any outcomes (p > 0.030).
conclusionsThese cross-sectional findings suggest that higher levels of MVPA are associated with more favorable metabolic profiles among individuals with or at risk for knee osteoarthritis. Key Points • Replacing 10 min/day of stationary time with moderate-to-vigorous physical activity was associated with lower odds of type 2 diabetes, and reductions in BMI and abdominal circumference in individuals with or at risk for knee osteoarthritis • Substituting light physical activity for stationary time had minimal impact on metabolic health, highlighting the importance of activity intensity • Even modest, achievable changes (e.g., ~ 10 min/day of MVPA, such as brisk walking) were theoretically associated with improved metabolic health in individuals with or at risk for knee osteoarthritis.
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