ReviewCell transplantation
Hotspots and trends in stem cell therapy for ligament injuries: A bibliometric analysis (2001-2025).
Review in Cell transplantation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ligament injuries can lead to lasting instability and early joint degeneration despite rehabilitation or surgery. Stem cell therapies may aid regeneration, but studies are highly variable. Bibliometric analysis can summarize trends, hotspots, and research gaps. We searched the Web of Science Core Collection for English-language original articles on stem cell therapy for ligament injuries from 2001 to 2025 on April 2, 2025, excluding non-original publications. Publication and citation trends were summarized, and co-authorship, co-citation, and keyword networks were mapped using Excel, VOSviewer, CiteSpace, and Bibliometric.com. A total of 599 articles were included, with steadily increasing annual publications. The United States and China were leading contributors, with strong collaboration networks involving major institutions such as the University of Pittsburgh and Zhejiang University. Keyword analyses identified seven main themes spanning mechanisms, clinical translation, tissue engineering, surgery/grafting, injury models, biomechanics, and biomaterials. Recent hotspots included "inflammation" and "artificial ligament". Stem cell research for ligament injuries is increasingly focused on mechanisms and biomaterials, but evidence is still mainly preclinical and inconsistent. Better comparative clinical studies and standardized, well-defined biomaterial-cell approaches are needed.
Indexed as
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.