Evidence map›Paper›PMID 42350786›Full record

ArticleMolecular psychiatry2026

Widespread synaptic density loss in schizophrenia follows molecular and network architecture.

Sidhant Chopra, Patrick D Worhunsky, Mika Naganawa, Xi-Han Zhang, Ashlea Segal, Loïc Labache, Edwina Orchard, Vanessa Cropley, Stephen Wood, Gustavo A Angarita and 10 more

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Sidhant ChopraDepartment of Psychology, Yale University, New Haven, CT, USA. sidhantchopra4@gmail.com.ORCID http://orcid.org/0000-0003-0866-3477
Patrick D WorhunskyDepartment of Psychiatry, Yale University, New Haven, CT, USA.
Mika NaganawaDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-4408-2621
Xi-Han ZhangDepartment of Psychology, Yale University, New Haven, CT, USA.ORCID http://orcid.org/0000-0003-2630-0063
Ashlea SegalDepartment of Neuroscience, Yale University, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-7451-6195
Loïc LabacheDepartment of Psychiatry, Brain Health Institute, Rutgers University, Piscataway, NJ, USA.ORCID http://orcid.org/0000-0002-5733-0743
Edwina OrchardDepartment of Psychology, Yale University, New Haven, CT, USA.
Vanessa CropleyOrygen, The National Centre of Excellence in Youth Mental Health, Parkville, Melbourne, VIC, Australia.
Stephen WoodOrygen, The National Centre of Excellence in Youth Mental Health, Parkville, Melbourne, VIC, Australia.ORCID http://orcid.org/0000-0003-4186-5919
Gustavo A AngaritaDepartment of Psychiatry, Yale University, New Haven, CT, USA.ORCID http://orcid.org/0000-0001-5568-9878
Kelly CosgroveDepartment of Psychiatry, Yale University, New Haven, CT, USA.ORCID http://orcid.org/0000-0003-1351-9576
David MatuskeyDepartment of Psychiatry, Yale University, New Haven, CT, USA.ORCID http://orcid.org/0000-0001-7508-6572
Nabeel B NabulsiDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.ORCID http://orcid.org/0000-0001-8129-0051
Yiyun HuangDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.
Richard E CarsonDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-9338-7966
Irina EsterlisDepartment of Psychology, Yale University, New Haven, CT, USA.ORCID http://orcid.org/0000-0001-6293-1458
Patrick D SkosnikDepartment of Psychiatry, Yale University, New Haven, CT, USA.
Deepak C D'SouzaDepartment of Psychiatry, Yale University, New Haven, CT, USA.ORCID http://orcid.org/0000-0003-3141-1462
Avram J Holmes *Department of Psychiatry, Brain Health Institute, Rutgers University, Piscataway, NJ, USA.ORCID http://orcid.org/0000-0001-6583-803X
Rajiv Radhakrishnan *Department of Psychiatry, Yale University, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-8220-655X

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Functional genomics of the human connectome in psychiatric illnessR01MH120080 · NIMH · YALE UNIVERSITY · PI AVRAM J HOLMES, Thomas Boon Thye Yeo · 2019 to 2026
$4.8M
Brain and Behavior Research Foundation (Brain & Behavior Research Foundation) Young Investigator GrantNCATS NIH HHS UL1 TR001863University of Melbourne (Melbourne University) McKenzie FellowshipU.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH120080
6 · The paper itself

Abstract

Converging neuroimaging, genetic, and post-mortem evidence highlights the fundamental role of synaptic density reductions in schizophrenia pathogenesis. However, the brain-wide spatial pattern of these alterations and the mechanisms underlying this patterning remain to be established. Here, using [

Identifiers

PMID42350786

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.