ArticleBMC infectious diseases2026
Decentralized point-of-care HBV viral load testing for HBs Ag positive pregnant women in Mali, a prospective study.
Article in BMC infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundHepatitis B virus (HBV) infection remains a major public health challenge, particularly in sub‑Saharan Africa, where mother‑to‑child transmission (MTCT) is a leading cause of chronic infection. Perinatal HBV acquisition carries a high risk of chronic disease, yet prevention efforts are limited by restricted access to HBV DNA testing. Simplified point‑of‑care viral load assays, such as Xpert
methodsA cross-sectional study was conducted between June 2024 and May 2025 among pregnant woman attending antenatal care at different levels of the health system pyramid in Mali. The study sites included Referral Health Centers in Commune III of Bamako, Bla, and Sikasso, as well as Community Health Centers in Djibouria (Kéniéba district) and Badialan (Commune III, Bamako). Pregnant women testing positive for HBs Ag by a rapid test were enrolled. Venous blood (4 mL) was collected for HBV viral load quantification using the Xpert
resultsAmong 2,952 pregnant women screened, 205 were HBsAg positive (prevalence of 6.9%). After excluding hemolyzed samples, 191 women underwent HBV viral load testing. Overall, 64.0% had detectable HBV DNA; among these, 69.9% had viral loads < 2,000 IU/mL, while 5.7% had levels > 200,000 IU/mL. Viral load was not associated with maternal age or gestational age but was significantly associated with antiviral treatment status (p < 0.001). Same-day results were more frequent in decentralized laboratories with on-site GeneXpert testing than in the central laboratory (23.5% vs. 4.4%). However, in both settings, most results were returned after more than four days, with a significant difference in turnaround time distribution (p < 0.001).
conclusionHBV infection remains highly endemic among pregnant women in Mali, with a meaningful proportion presenting with high viral loads associated with increased risk of mother-to-child transmission. Decentralized Xpert
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