Evidence map›Paper›PMID 42351210›Full record

ArticleArthritis research & therapy2026

Tripartite motif containing 21 autoimmunity primes CD8

Yulu Qiu, Qin Wu, Lu Liu, Wenjuan Zhao, Yue Wang, Fang Wang, Wenfeng Tan

Abstract read
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In one paragraph

Article in Arthritis research & therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Yulu QiuDepartment of Rheumatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Qin WuDepartment of Rheumatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Lu LiuDepartment of Rheumatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Wenjuan ZhaoDepartment of Rheumatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Yue WangDepartment of Rheumatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Fang WangDepartment of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China. wangfangheart@njmu.edu.cn.
Wenfeng TanDepartment of Rheumatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China. tw2006@njmu.edu.cn.

Funding

National Natural Science Foundation of China,China 82101878National Natural Science Foundation of China,China 82171794
6 · The paper itself

Abstract

backgroundAnti-Ro52 [Tripartite Motif Containing 21 (TRIM21)] antibodies are strongly associated with interstitial lung disease (ILD) in connective tissue diseases (CTDs), yet the underlying mechanisms remain elusive. This study aimed to elucidate the mechanisms by which TRIM21 autoimmunity drives ILD using an in vivo model.

methodsA murine model of TRIM21 autoimmunity was established by immunizing mice with full-length recombinant TRIM21 protein. Lung immune infiltration and antibody production were assessed. To mimic viral triggers, mice received poly(I:C). Immune cell subsets and transcriptional changes were analyzed using flow cytometry, RNA sequencing, and immunohistochemistry.

resultsTRIM21 immunization induced systemic autoantibody production and B cell activation, which were associated with selective pulmonary inflammation marked by IgG deposition. Upon poly(I:C) challenge, lung inflammation was markedly exacerbated, with increased infiltration of CD8

conclusionThese findings support a pathogenic role for anti-Ro52/TRIM21 autoimmunity in CTD-associated ILD. Our in vivo model reveals a lung-predominant inflammatory response associated with CD8

Indexed as

AutoimmunityCD8-Positive T-LymphocytesLung Diseases, InterstitialPneumoniaRibonucleoproteinsAnimalsAutoantibodiesDisease Models, AnimalFemaleFlow CytometryMiceMice, Inbred C57BLSS-A AntigenTRIM21 ProteinAutoantibodiesRibonucleoproteinsSS-A AntigenTRIM21 ProteinCD8+ cellsConnective tissue diseasesInterstitial lung diseaseTRIM21

Identifiers

PMID42351210
PMCPMC13560342

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.