Evidence map›Paper›PMID 42351637›Full record

ReviewBiomedicines2026

A Review of the Potential Therapeutic Benefits of Quercetin for Uterine-Related Conditions.

Michael A Leone, Georgia Kurman, Madeline Bright, Peter K Gregersen, Christine N Metz

Abstract readReview
In one paragraph

Review in Biomedicines, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Michael A LeoneSchool of Health Sciences, Hofstra University, Hempstead, NY 11549, USA.
Georgia KurmanSchool of Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY 11549, USA.ORCID 0009-0000-8858-2604
Madeline BrightSchool of Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY 11549, USA.ORCID 0009-0003-3933-1771
Peter K GregersenInstitute of Molecular Medicine, Feinstein Institutes, Northwell Health, Manhasset, NY 11030, USA.ORCID 0000-0003-1613-1518
Christine N MetzInstitute of Molecular Medicine, Feinstein Institutes, Northwell Health, Manhasset, NY 11030, USA.ORCID 0000-0002-1013-1691

Funding

Anonymous DAF GRTRINorthwell Health Innovations TNCOR
6 · The paper itself

Abstract

Quercetin is a naturally occurring flavonoid found in fruits, vegetables, and teas that is widely available as a dietary supplement. Numerous studies have investigated quercetin's therapeutic potential across a broad range of diseases and conditions. Collectively, these studies reveal its anti-inflammatory, antioxidant, anti-proliferative, anti-cancer, anti-fibrotic, antibacterial, endocrine-modulating, and senolytic properties, establishing quercetin as a polypharmacologic agent with diverse biological activities. This review describes quercetin's biochemical properties, bioavailability, and proposed mechanisms of action. It highlights the unique characteristics of the human uterus vs. other species and evaluates published evidence from pre-clinical and clinical studies supporting quercetin's pleiotropic effects and potential therapeutic benefits for six uterine-related conditions: endometrial cancer, endometriosis, adenomyosis, uterine infections, uterine fibroids, and polycystic ovary syndrome (PCOS). The findings support that quercetin targets multiple endometrial and other uterine cell types and may attenuate key pathological processes relevant to uterine disease. However, robust human clinical evidence supporting quercetin's efficacy is generally lacking. Critical knowledge gaps and translational barriers to advancing quercetin from a 'promising preclinical candidate' into an 'evidence-based therapeutic' for improving uterine health are discussed.

Indexed as

adenomyosischronic endometritisendometrial cancerendometriosisendometriumflavonoidspolycystic ovary diseasequercetinuterine fibroidsuterine health

Identifiers

PMID42351637
PMCPMC13295906

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.