Evidence map›Paper›PMID 42351691›Full record

ReviewBiomedicines2026

Obstructive Sleep Apnea and Cardiovascular Disease: Mechanisms, Diagnostics, and Emerging Therapeutic Approaches.

Bridget R Alber, Emily C Cheung, Rebekah Russo, Vivek Jain, Kathryn Jaques Schunke, David Mendelowitz, Matthew W Kay

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biomedicines, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Bridget R AlberDepartment of Biomedical Engineering, The George Washington University, Washington, DC 20052, USA.ORCID 0000-0002-2953-1193
Emily C CheungDepartment of Biomedical Engineering, The George Washington University, Washington, DC 20052, USA.
Rebekah RussoDepartment of Biomedical Engineering, The George Washington University, Washington, DC 20052, USA.ORCID 0000-0001-6467-5611
Vivek JainDivision of Pulmonary, Critical Care & Sleep Medicine, Department of Medicine, The George Washington University, Washington, DC 20037, USA.
Kathryn Jaques SchunkeDepartment of Cell and Molecular Biology, University of Hawaii, Honolulu, HI 96813, USA.ORCID 0000-0002-0815-8457
David MendelowitzDepartment of Pharmacology and Physiology, The George Washington University, Washington, DC 20052, USA.ORCID 0000-0001-7107-1832
Matthew W KayDepartment of Biomedical Engineering, The George Washington University, Washington, DC 20052, USA.ORCID 0000-0003-2756-5055

Funding

UH Hilo COP A&RP20GM103466 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI Peter R Hoffmann · 2012 to 2026
$60.3M
TRPA1 Physiology in Diabetes, Metabolic Syndrome, and MetabolismP20GM113134 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI MARIANA GERSCHENSON · 2017 to 2026
$21.5M
Hypothalamic neuron activation to blunt myocardial remodeling during chronic sleep apneaR01HL146169 · NHLBI · GEORGE WASHINGTON UNIVERSITY · PI KAY, MATTHEW W. · 2019 to 2022
$2.6M
Novel Mechanisms that Restore Cardiac Parasympathetic Activity Limits Arrhythmias and Cardiac Dysfunction After Myocardial InfarctionR01HL147279 · NHLBI · GEORGE WASHINGTON UNIVERSITY · PI KAY, MATTHEW W., MENDELOWITZ, DAVID · 2020 to 2023
$2.3M
NHLBI NIH HHS R01 HL146169NHLBI NIH HHS R01 HL147279NIGMS NIH HHS P20 GM113134NIH HHS HL146169NIH HHS HL147279NIH HHS P20GM103466NIH HHS P20GM113134
6 · The paper itself

Abstract

Current diagnostic methods for OSA and CSA are costly, unreliable, and the therapeutic options are limited, with varying efficacy across patients. As the prevalence of sleep apnea and cardiovascular disease continue to rise, identifying innovative therapies through advances in biomedicine and personalized medicine has become increasingly critical. This review discusses the mechanistic links between sleep apnea and subsequent cardiovascular outcomes from a technical perspective, focusing on innovations currently applied to the diagnosis and treatment of sleep apnea, and opportunities for further advancement in the field.

Indexed as

cardiovascular diseasecentral sleep apneacontinuous positive airway pressureepigeneticsnerve stimulationobstructive sleep apneaprecision medicine

Identifiers

PMID42351691
PMCPMC13297110

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.