Evidence map›Paper›PMID 42351968›Full record

ArticleAntioxidants (Basel, Switzerland)2026

Urolithin A-Enhanced Multi-Bioactive Formulation Mitigates Cyclophosphamide-Induced Premature Ovarian Failure Through Suppression of Oxidative-Inflammatory Stress and Preservation of Follicle Fate.

Yangyan Dai, Silu Zhang, Lijia Yang, Penglong Liu, Tingfeng Zhang, Hailong Li, Yuchen Pang, Shijing Ma, Yehui Zhang, Tiantian Zhao

Abstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yangyan DaiWONDERLAB Institute of Microecology and Nutrition, Shenzhen Porshealth Bioengineering Co., Ltd., Shenzhen 518000, China.
Silu ZhangWONDERLAB Institute of Microecology and Nutrition, Shenzhen Porshealth Bioengineering Co., Ltd., Shenzhen 518000, China.ORCID 0009-0004-7385-272X
Lijia YangSericulture & Agri-food Research Institute Guangdong Academy of Agricultural Sciences, Key Laboratory of Functional Foods, Ministry of Agriculture and Rural Affairs, Guangdong Key Laboratory of Agricultural Products Processing, Guangzhou 510610, China.
Penglong LiuSericulture & Agri-food Research Institute Guangdong Academy of Agricultural Sciences, Key Laboratory of Functional Foods, Ministry of Agriculture and Rural Affairs, Guangdong Key Laboratory of Agricultural Products Processing, Guangzhou 510610, China.
Tingfeng ZhangSericulture & Agri-food Research Institute Guangdong Academy of Agricultural Sciences, Key Laboratory of Functional Foods, Ministry of Agriculture and Rural Affairs, Guangdong Key Laboratory of Agricultural Products Processing, Guangzhou 510610, China.
Hailong LiWONDERLAB Institute of Microecology and Nutrition, Shenzhen Porshealth Bioengineering Co., Ltd., Shenzhen 518000, China.
Yuchen PangWONDERLAB Institute of Microecology and Nutrition, Shenzhen Porshealth Bioengineering Co., Ltd., Shenzhen 518000, China.
Shijing MaWONDERLAB Institute of Microecology and Nutrition, Shenzhen Porshealth Bioengineering Co., Ltd., Shenzhen 518000, China.
Yehui ZhangSericulture & Agri-food Research Institute Guangdong Academy of Agricultural Sciences, Key Laboratory of Functional Foods, Ministry of Agriculture and Rural Affairs, Guangdong Key Laboratory of Agricultural Products Processing, Guangzhou 510610, China.
Tiantian ZhaoSericulture & Agri-food Research Institute Guangdong Academy of Agricultural Sciences, Key Laboratory of Functional Foods, Ministry of Agriculture and Rural Affairs, Guangdong Key Laboratory of Agricultural Products Processing, Guangzhou 510610, China.ORCID 0000-0003-4092-1261

Funding

Department of Science and Technology of Guangdong Province 2025A1515010320Guangdong Academy of Agricultural Sciences R2023PY-JG016Guangdong Academy of Agricultural Sciences R2023PY-QY011National Key Research and Development Program 2024YFF1106000
6 · The paper itself

Abstract

Cyclophosphamide (CTX)-induced premature ovarian failure (POF) is characterized by disruption of the follicular microenvironment, granulosa-cell loss, endocrine imbalance, and oxidative-inflammatory injury. Here, we evaluated two multi-bioactive formulations developed to enhance ovarian stress resilience: a base formulation containing coenzyme Q10, calcium L-5-methyltetrahydrofolate, and

Indexed as

cyclophosphamidefunctional food strategyhypothalamic-pituitary-ovarian axisoxidative stresspremature ovarian failureurolithin A

Identifiers

PMID42351968
PMCPMC13295883

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.