Evidence map›Paper›PMID 42352012›Full record

ArticleAntioxidants (Basel, Switzerland)2026

Effect of a Milk Protein Concentrate Supplement on Muscle Recovery and Oxidative Stress Following Knee and Hip Arthroplasty: A Randomized Control Trial.

Maria Spanoudaki, Stavros Kalogiannis, Antonios Cheimaras, Dimitrios Georgianos, Stavros Pellios, Kyriaki Petridou, Thomas Apostolou, Constantinos Giaginis, Sousana Konstantinos Papadopoulou

Abstract read
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In one paragraph

Article in Antioxidants (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Maria SpanoudakiDepartment of Nutritional Sciences and Dietetics, School of Health Sciences, International Hellenic University, 570 01 Thessaloniki, Greece.
Stavros KalogiannisDepartment of Nutritional Sciences and Dietetics, School of Health Sciences, International Hellenic University, 570 01 Thessaloniki, Greece.ORCID 0000-0001-6127-6930
Antonios CheimarasDepartment of Nutritional Sciences and Dietetics, School of Health Sciences, International Hellenic University, 570 01 Thessaloniki, Greece.
Dimitrios GeorgianosSecond Orthopedic Clinic, 424 Military Hospital of Thessaloniki, New Efkarpia Ring Road, 564 29 Pavlos Melas, Greece.
Stavros PelliosFirst Orthopedic Clinic, 424 Military Hospital of Thessaloniki, New Efkarpia Ring Road, 564 29 Pavlos Melas, Greece.
Kyriaki PetridouDepartment of Nutritional Sciences and Dietetics, School of Health Sciences, Hellenic Mediterranean University, 723 00 Sitia, Crete, Greece.
Thomas ApostolouDepartment of Physiotherapy, School of Health Sciences, International Hellenic University, 570 01 Thessaloniki, Greece.
Constantinos GiaginisDepartment of Food Science and Nutrition, School of Environment, University of Aegean, 814 00 Myrina, Limnos, Greece.ORCID 0000-0003-2878-4831
Sousana Konstantinos PapadopoulouDepartment of Nutritional Sciences and Dietetics, School of Health Sciences, International Hellenic University, 570 01 Thessaloniki, Greece.ORCID 0000-0002-6408-6128

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPostoperative rehabilitation following Total Knee or Hip arthroplasty (TKA, THA respectively) for end-stage osteoarthritis is frequently characterized by oxidative stress and chronic-inflammation-induced muscle atrophy. This study investigated the efficacy of a milk protein concentrate supplement (MCPS) on oxidative stress, inflammation markers, and functional regains in patients undergoing TKA or THA.

methods88 participants (aged 55-80 years) were allocated to either an Intervention Group (IG, n = 44), receiving the MPCS, or a Control Group (CG, n = 44), following conventional nutrition for 15 weeks. Appendicular skeletal muscle mass (ASMM) was measured using bioelectrical impedance analysis and functionality through handgrip strength, gait speed, and static balance. 8-Isoprostane levels were quantified in plasma samples using the Enzyme-Linked Immunosorbent Assay(ELISA) method. C Reactive Protein (CRP) levels in serum specimens were measured. Data analysis was conducted, with adjustments made for age, gender, and comorbidities.

resultsThe IG demonstrated a significant increase in ASMM (Adj. mean change, Δ = +2.34 kg, 95% CI: 1.99 to 2.69,

conclusionsStructural nutritional intervention can effectively mitigate catabolic stress triggered by surgical treatment. Implementing such strategies into orthopedic care offers a practical approach to treat challenges often associated with postoperative muscle loss.

Indexed as

8-isoprostanesarthroplastyCRPmilk protein concentrateosteoarthritisskeletal muscle mass

Identifiers

PMID42352012
PMCPMC13296205

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.