Protein S-Nitrosylation in Heart Failure: A Compartment-Resolved Review of Mechanisms, Evidence Boundaries, and Translational Perspectives.

Miao Shi, Yongnan Li, Ziwei Zhu, Yafei Xie, Xiaowei Zhang

Abstract readReview

In one paragraph

Review in Antioxidants (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Miao ShiDepartment of Cardiology, Lanzhou University Second Hospital, Lanzhou University, Lanzhou 730000, China.

Yongnan LiDepartment of Cardiac Surgery, Lanzhou University Second Hospital, Lanzhou 730031, China.ORCID 0000-0003-0821-8875

Ziwei ZhuDepartment of Cardiology, Lanzhou University Second Hospital, Lanzhou University, Lanzhou 730000, China.

Yafei XieDepartment of Cardiology, Lanzhou University Second Hospital, Lanzhou University, Lanzhou 730000, China.

Xiaowei ZhangDepartment of Cardiology, Lanzhou University Second Hospital, Lanzhou University, Lanzhou 730000, China.ORCID 0000-0003-2577-5219

Funding

Gansu science and Technology Department Project 24JRRA924Gansu science and Technology Department Project 25JRRA1270Lanzhou Chengguan District Science and Technology Plan Project 2024JSCX0037National Natural Science Foundation of China 82460084Project of Lanzhou Science and Technology Bureau 2024-3-22Provincial Talent Project 2024RCXM44

6 · The paper itself

Abstract

Heart failure (HF) remains a major cause of morbidity and mortality despite substantial therapeutic progress, and important phenotype-specific treatment gaps persist. Protein S-nitrosylation (SNO) is a reversible cysteine-centered post-translational modification (PTM) whose reported associations with selected HF-relevant contexts, including vascular-endothelial dysfunction, mitochondrial-energetic remodeling, Ca

Indexed as

heart failureheart failure with preserved ejection fractionnitric oxidenitrosative stressS-nitrosylation

Identifiers

PMID42352022

DOI10.3390/antiox15060716

PMCPMC13295539

What Socratic holds

Textmetadata

LicenceCC BY

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.