Metabolism-Associated Hepatotoxicity of Gatifloxacin in Zebrafish Larvae.

Rong Shen, Yichang Yu, Yue Ma, Ran Yu, Rong Lan, Yuning Zhang

Abstract read

In one paragraph

Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rong ShenSchool of Bioengineering, Beijing Polytechnic University, Beijing 100176, China.

Yichang YuChongqing Research Academy of Eco-Environmental Science, Chongqing 401336, China.

Yue MaSchool of Bioengineering, Beijing Polytechnic University, Beijing 100176, China.

Ran YuSchool of Bioengineering, Beijing Polytechnic University, Beijing 100176, China.

Rong LanSchool of Bioengineering, Beijing Polytechnic University, Beijing 100176, China.

Yuning ZhangSchool of Bioengineering, Beijing Polytechnic University, Beijing 100176, China.

Funding

Beijing Polytechnic University 2024X006-KXZ

6 · The paper itself

Abstract

Gatifloxacin (GTFX), a fourth-generation fluoroquinolone, causes metabolic disturbances in mammals, but its hepatotoxic mechanisms in aquatic vertebrates remain unclear. This study investigated whether GTFX induces liver injury in zebrafish larvae through oxidative stress or alternative pathways. Larvae at 3 days post-fertilization were exposed to 0.2-2.3 mg/mL GTFX for 48 h. Liver morphology, histopathology, intracellular reactive oxygen species (ROS), and expression of lipid metabolism (

Indexed as

Chemical and Drug Induced Liver InjuryGatifloxacinLiverZebrafishAnimalsLarvaLipid MetabolismOxidative StressReactive Oxygen SpeciesGatifloxacinReactive Oxygen Speciescytochrome P450gatifloxacinhepatotoxicitylipid metabolismnon-oxidative mechanismzebrafish larvae

Identifiers

PMID42352247

DOI10.3390/biom16060780

PMCPMC13297578

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.