Evidence map›Paper›PMID 42352257›Full record

ArticleBiomolecules2026

Aloperine Suppresses the Tumorigenicity of Esophageal Squamous Cell Carcinoma by Targeting the AP-1/IL-6/STAT3 Signaling Axis.

Ba-Fang Ma, Jun-Nan Ye, Die Bai, Chang Ge, Yingchao Guan, Yang Lou, Ya-Ping Liang, Na Bu, Wenhui Hao, Yasen Maimaitiyiming

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ba-Fang MaDepartment of Immunology, School of Basic Medical Sciences, Xinjiang Medical University, Urumqi 830011, China.
Jun-Nan YeDepartment of Immunology, School of Basic Medical Sciences, Xinjiang Medical University, Urumqi 830011, China.
Die BaiDepartment of Immunology, School of Basic Medical Sciences, Xinjiang Medical University, Urumqi 830011, China.
Chang GeDepartment of Immunology, School of Basic Medical Sciences, Xinjiang Medical University, Urumqi 830011, China.
Yingchao GuanXinjiang Key Laboratory of Molecular Biology for Endemic Diseases, Xinjiang Medical University, Urumqi 830011, China.
Yang LouDepartment of Immunology, School of Basic Medical Sciences, Xinjiang Medical University, Urumqi 830011, China.
Ya-Ping LiangXinjiang Key Laboratory of Molecular Biology for Endemic Diseases, Xinjiang Medical University, Urumqi 830011, China.
Na BuDepartment of Pharmacy, Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China.
Wenhui HaoXinjiang Key Laboratory of Molecular Biology for Endemic Diseases, Xinjiang Medical University, Urumqi 830011, China.
Yasen MaimaitiyimingDepartment of Immunology, School of Basic Medical Sciences, Xinjiang Medical University, Urumqi 830011, China.ORCID 0000-0002-1990-4857

Funding

National Natural Science Foundation of China 82460714
6 · The paper itself

Abstract

Esophageal squamous cell carcinoma (ESCC) is an aggressive malignancy with a poor prognosis, largely due to therapeutic resistance and the limited availability of effective targeted therapies. Aloperine (ALO), a natural alkaloid derived from

Indexed as

Esophageal NeoplasmsEsophageal Squamous Cell CarcinomaInterleukin-6PiperidinesSTAT3 Transcription FactorTranscription Factor AP-1AnimalsApoptosisCell Line, TumorCell ProliferationCisplatinHumansMaleMiceQuinolizidine AlkaloidsQuinolizidinesaloperineCisplatinInterleukin-6PiperidinesQuinolizidine AlkaloidsQuinolizidinesSTAT3 protein, humanSTAT3 Transcription FactorTranscription Factor AP-1AloperineAP-1 transcription factorapoptosisesophageal squamous cell carcinomaIL-6/STAT3 signaling

Identifiers

PMID42352257
PMCPMC13297383

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.