ReviewBiomolecules2026
Role of Microbial Toxins in Neurodegenerative Diseases: Insights and Future Perspectives.
Review in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
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Abstract
Neurodegenerative disorders, including Parkinson's, Alzheimer's, and multiple sclerosis, are significant global health issues characterized by escalating neuronal dysfunction and cognitive decline. Studies suggest that microbial toxins originating from fungi and bacteria may contribute to neurodegenerative processes by altering neuronal homeostasis in several ways. Toxins formerly associated with infectious diseases have now been associated with neuroinflammation, oxidative stress, and protein misfolding, all of which are common in neurodegenerative diseases. According to recent studies, microbial toxins generated by the gut microbiota may cross the blood-brain barrier and possibly contribute to neuroinflammatory cascades linked to the development of neurodegenerative diseases. The complex interplay of microbial metabolites, microbial responses, and mitochondrial dysfunction demonstrates the diverse character of neurodegenerative processes. This review delves into the current understanding of microbial toxins, which are produced by diverse bacteria and can have a direct or indirect impact on neuronal health via multiple signaling pathways. Understanding the signaling mechanisms of microbial and toxin-mediated neurodegenerative diseases could result in the development of effective alternative therapeutics for neurological disorders.
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