ArticleCancers2026
The GAPP Aggressivity Score Correlates with Total Enriched Somatic Variant Burden in Sporadic Pheochromocytoma-A Pilot Study.
Article in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundPheochromocytomas and paragangliomas (PPGLs) can be metastatic in up to 30% of cases. To assess this risk, scoring systems like PASS and GAPP were developed, yet it is unclear whether these scores correlate with somatic genetic alterations.
methodsA retrospective pilot study. Twenty patients with sporadic pheochromocytoma, stratified into high- and low-risk groups based on GAPP and PASS scores. Somatic variant burden, derived from whole-exome sequencing, and clinical variables were compared between groups.
resultsSix patients (30.0%) comprised the high-risk group; all had PASS scores >4 and GAPP scores indicating moderately differentiated PPGLs. Compared with the low-risk group, the high-risk group had larger tumors (4.7 vs. 3.4 cm,
conclusionsHigher pathological severity scores are associated with increased rates of severe molecular somatic variants. The stronger link between GAPP score and genetic alteration rates suggests it may better reflect the genomic complexity of sporadic PPGLs.
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