ArticleInternational journal of molecular sciences2026
When Protection Turns Pathogenic: Dual Compartment Functions of Myeloid YB-1 in Renal IRI.
Anna Leitz, Yili Chen, Xiyang Liu, Yingying Gao, Jialin Wang, Ina Verena Martin, Rafaela Rawinski, Rafael Kramann, Tammo Ostendorf, Ute Raffetseder
Abstract read
In one paragraphArticle in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
10 authors.
Anna LeitzDepartment of Nephrology and Clinical Immunology, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany.ORCID 0009-0001-0993-1595 Yili ChenDepartment of Nephrology and Clinical Immunology, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany.
Xiyang LiuDepartment of Nephrology and Clinical Immunology, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany.
Yingying GaoDepartment of Nephrology and Clinical Immunology, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany.
Jialin WangDepartment of Nephrology and Clinical Immunology, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany.
Ina Verena MartinDepartment of Nephrology and Clinical Immunology, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany.ORCID 0000-0003-1638-8604 Rafaela RawinskiDepartment of Nephrology and Clinical Immunology, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany.ORCID 0009-0003-6915-9896 Rafael KramannDepartment of Nephrology and Clinical Immunology, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany.
Tammo OstendorfDepartment of Nephrology and Clinical Immunology, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany.ORCID 0000-0003-2889-5371 Ute RaffetsederDepartment of Nephrology and Clinical Immunology, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany.
Funding
China Scholarship Council (CSC) 201806380070China Scholarship Council (CSC) 202008310175China Scholarship Council (CSC) 202308230155German Research Foundation (Deutsche Forschungsgemeinschaft) KFO 5011German Research Foundation (Deutsche Forschungsgemeinschaft) OS 196/2-1German Research Foundation (Deutsche Forschungsgemeinschaft) OS 196/4-1German Research Foundation (Deutsche Forschungsgemeinschaft) RA 740/11-1German Research Foundation (Deutsche Forschungsgemeinschaft) RA 740/8-1German Research Foundation (Deutsche Forschungsgemeinschaft) RA 740/9-1German Research Foundation (Deutsche Forschungsgemeinschaft) SFB/TRR57 P17
6 · The paper itselfAbstract
Acute kidney injury (AKI) caused by ischemia-reperfusion injury (IRI) involves rapid activation of innate immune responses, in which myeloid-derived immune cells critically shape injury severity. Y-box binding protein 1 (YB-1) regulates pro-inflammatory gene expression intracellularly and can be secreted to function extracellularly, yet how these two compartments jointly influence early IRI pathology remains poorly understood. To dissect the roles of intracellular myeloid
Indexed as
Acute Kidney InjuryMyeloid CellsReperfusion InjuryY-Box-Binding Protein 1AnimalsExtracellular TrapsInflammationKidneyMaleMiceMice, KnockoutNeutrophil InfiltrationNeutrophilsReceptors, IgGTranscription FactorsReceptors, IgGTranscription FactorsY-Box-Binding Protein 1Ybx1 protein, mouseacute kidney injuryFc gamma receptor CD16immune complexesischemia–reperfusion injurymyeloid cellsneutrophil extracellular trapsrenal inflammationYB-1
Identifiers
PMID42352963
PMCPMC13299933
What Socratic holds
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